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Diagnostic criteria for cancer cachexia: reduced food intake and inflammation predict weight loss and survival in an international, multi-cohort analysis
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2021-08-27 , DOI: 10.1002/jcsm.12756
Lisa Martin 1 , Maurizio Muscaritoli 2 , Isabelle Bourdel-Marchasson 3 , Catherine Kubrak 4 , Barry Laird 5 , Bruno Gagnon 6 , Martin Chasen 7 , Ioannis Gioulbasanis 8 , Ola Wallengren 9 , Anne C Voss 10 , Francois Goldwasser 11 , R Thomas Jagoe 12 , Chris Deans 13 , Federico Bozzetti 14 , Florian Strasser 15 , Lene Thoresen 16 , Sean Kazemi 4 , Vickie Baracos 4 , Pierre Senesse 17
Affiliation  

Cancer-associated weight loss (WL) associates with increased mortality. International consensus suggests that WL is driven by a variable combination of reduced food intake and/or altered metabolism, the latter often represented by the inflammatory biomarker C-reactive protein (CRP). We aggregated data from Canadian and European research studies to evaluate the associations of reduced food intake and CRP with cancer-associated WL (primary endpoint) and overall survival (OS, secondary endpoint).

中文翻译:

癌症恶病质的诊断标准:在一项国际多队列分析中,减少食物摄入和炎症可预测体重减轻和存活率

癌症相关体重减轻 (WL) 与死亡率增加有关。国际共识表明,WL 是由食物摄入减少和/或新陈代谢改变的可变组合驱动的,后者通常以炎症生物标志物 C 反应蛋白 (CRP) 为代表。我们汇总了来自加拿大和欧洲研究的数据,以评估减少食物摄入和 CRP 与癌症相关 WL(主要终点)和总生存期(OS,次要终点)的关联。
更新日期:2021-10-15
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