Cancer-associated weight loss (WL) associates with increased mortality. International consensus suggests that WL is driven by a variable combination of reduced food intake and/or altered metabolism, the latter often represented by the inflammatory biomarker C-reactive protein (CRP). We aggregated data from Canadian and European research studies to evaluate the associations of reduced food intake and CRP with cancer-associated WL (primary endpoint) and overall survival (OS, secondary endpoint).

中文翻译：

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癌症恶病质的诊断标准：在一项国际多队列分析中，减少食物摄入和炎症可预测体重减轻和存活率

癌症相关体重减轻 (WL) 与死亡率增加有关。国际共识表明，WL 是由食物摄入减少和/或新陈代谢改变的可变组合驱动的，后者通常以炎症生物标志物 C 反应蛋白 (CRP) 为代表。我们汇总了来自加拿大和欧洲研究的数据，以评估减少食物摄入和 CRP 与癌症相关 WL（主要终点）和总生存期（OS，次要终点）的关联。