Iranian Polymer Journal ( IF 2.4 ) Pub Date : 2021-08-26 , DOI: 10.1007/s13726-021-00972-3 Mei Lv 1, 2 , Wenjing Lv 1 , Haozheng Chen 1 , Jing Liu 1 , Fandong Kong 1 , Shuling Liu 1 , Litao Wang 1 , Fei Zheng 3
|
Polyetheretherketone (PEEK) has been considered as an excellent orthopedic implant material due to its similar elastic modulus to that of human bones. However, many obstacles including the bio-inertness nature and inferior osteoconduction of PEEK limit its wide applications in clinics. Nano hydroxyapatite (HA) and zirconium dioxide (ZrO2) were incorporated into PEEK to fabricate HA/ZrO2/PEEK biocomposites. The result of wettability of these biocomposites showed that the introduction of the ZrO2 and HA nanoparticles in PEEK could enhance its hydrophilic property at 1–2% HA and 1–5% ZrO2 concentrations. The biotribological properties and bioactivity of PEEK and HA/ZrO2/PEEK biocomposites were investigated in detail. The friction coefficient of these biocomposites increased with the increase of frequency and their wear width increased obviously with the increase of load. Biological and tribological experiments indicated that bovine serum possessed the best lubrication performance, and the 1%HA–1%ZrO2 and 2%HA–5%ZrO2 samples exhibited the lowest friction coefficient and wear rate. Then, the in vitro tests demonstrated that the HA/ZrO2/PEEK biocomposites exhibited improved cell activity and alkaline phosphatase activity than pure PEEK, and both 1%HA/1%ZrO2/PEEK and 2%HA/5%ZrO2/PEEK biocomposite samples could better promote bone calcification. The PEEK biocomposite with 2 wt% HA and 5 wt% ZrO2 nanoparticles exhibited the best tribological properties and bioactivity, which could be expected to develop a kind of potential medical material for practical clinical applications.
Graphic abstract
中文翻译：
纳米二氧化锆和羟基磷灰石增强聚醚醚酮（HA/ZrO2/PEEK）生物复合材料的生物摩擦学特性
聚醚醚酮（PEEK）由于其与人体骨骼的弹性模量相似，被认为是一种优良的骨科植入材料。然而，PEEK的生物惰性和骨传导性差等诸多障碍限制了其在临床上的广泛应用。将纳米羟基磷灰石 (HA) 和二氧化锆 (ZrO 2 ) 结合到 PEEK 中以制造 HA/ZrO 2 /PEEK 生物复合材料。这些生物复合材料的润湿性结果表明，在 PEEK 中引入 ZrO 2和 HA 纳米粒子可以增强其在 1-2% HA 和 1-5% ZrO 2浓度下的亲水性。PEEK和HA/ZrO 2 的生物摩擦学特性和生物活性/PEEK 生物复合材料进行了详细研究。这些生物复合材料的摩擦系数随着频率的增加而增加，其磨损宽度随着载荷的增加而明显增加。生物学和摩擦学实验表明，牛血清具有最好的润滑性能，1%HA–1%ZrO 2和2%HA–5%ZrO 2样品的摩擦系数和磨损率最低。然后，体外测试表明 HA/ZrO 2 /PEEK 生物复合材料比纯 PEEK 具有更高的细胞活性和碱性磷酸酶活性，1%HA/1%ZrO 2 /PEEK 和 2%HA/5%ZrO 2/PEEK生物复合样品可以更好地促进骨钙化。含有2 wt% HA和5 wt% ZrO 2纳米颗粒的PEEK生物复合材料表现出最佳的摩擦学性能和生物活性，有望开发出一种具有实际临床应用潜力的医用材料。
京公网安备 11010802027423号