Journal of Nanoparticle Research ( IF 2.1 ) Pub Date : 2021-08-27 , DOI: 10.1007/s11051-021-05311-4 Keita Mikami 1 , Hiroyasu Kanetaka 1, 2 , Yoshifumi Saijo 1 , Maiko Furuya 2 , Kotone Yokota 2 , Taishi Yokoi 3 , Masakazu Kawashita 3
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Neutron capture therapy, such as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT), has been attracting much attention as a next-generation radiotherapy. Nanoparticles containing both boron and gadolinium can accumulate in tumours because of the enhanced permeability and retention (EPR) effect, thereby simultaneously rendering the benefits of BNCT and GdNCT. In this study, we obtained flake-shaped gadolinium borate (GdBO3) nanoparticles, approximately 80 nm in length and 20 nm in width, by hydrothermal treatment of a solution containing gadolinium chloride, boric acid, and polyethylene glycol at 220 °C for 24 h. These GdBO3 nanoparticles did not show any serious cytotoxic effect against human umbilical vein endothelial cells over a concentration range of 3–300 µg·mL–1. The results suggest that GdBO3 nanoparticles can accumulate in tumours because of the EPR effect and can function as boron and gadolinium nanocarriers for neutron capture therapy. However, further in vitro and in vivo studies are needed for the application of these nanoparticles in neutron capture therapy.
Graphical abstract
中文翻译：
用于中子俘获治疗的硼酸钆纳米颗粒的水热合成和初步细胞毒性评估
硼中子俘获疗法（BNCT）和钆中子俘获疗法（GdNCT）等中子俘获疗法作为下一代放射疗法备受关注。由于增强的渗透性和保留（EPR）效应，包含硼和钆的纳米颗粒可以在肿瘤中积累，从而同时呈现 BNCT 和 GdNCT 的益处。在这项研究中，我们获得了片状钆硼酸盐（GdBO 3在220℃下）的纳米颗粒，在长度约80nm，宽度为20nm，通过含有氯化钆，硼酸，和聚乙二醇的溶液的水热处理24 H。这些 GdBO 3在 3–300 µg·mL –1的浓度范围内，纳米颗粒对人脐静脉内皮细胞没有表现出任何严重的细胞毒性作用。结果表明，由于EPR效应，GdBO 3纳米颗粒可以在肿瘤中积累，并且可以作为硼和钆纳米载体用于中子捕获治疗。然而，这些纳米颗粒在中子俘获疗法中的应用还需要进一步的体外和体内研究。
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