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Patient-reported quality of life with interstitial partial breast brachytherapy and external beam whole breast radiotherapy: a comparison using propensity-score matching
Journal of Contemporary Brachytherapy ( IF 1.1 ) Pub Date : 2021-07-10 , DOI: 10.5114/jcb.2021.107690 Tabassum Wadasadawala 1 , Priyamvada Maitre 2 , Shwetabh Sinha 2 , Vani Parmar 3 , Rima Pathak 2 , Mithila Gaikar 4 , Shalini Verma 2 , Rajiv Sarin 2
Journal of Contemporary Brachytherapy ( IF 1.1 ) Pub Date : 2021-07-10 , DOI: 10.5114/jcb.2021.107690 Tabassum Wadasadawala 1 , Priyamvada Maitre 2 , Shwetabh Sinha 2 , Vani Parmar 3 , Rima Pathak 2 , Mithila Gaikar 4 , Shalini Verma 2 , Rajiv Sarin 2
Affiliation
Introduction
The aim of this study was to compare patient-reported quality of life (QOL) scores after accelerated partial breast irradiation (APBI) using interstitial brachytherapy vs. external beam whole breast radiotherapy (WBRT) for breast cancer.
Material and methods
Women with breast cancer treated with WBRT or APBI after breast conservation surgery were enrolled in this prospective study. Single cross-sectional QOL assessment was performed using EORTC QLQ-C30 and BR-23 questionnaires. Patients treated with APBI were propensity-score matched to similar cohort of patients treated with WBRT. QOL scores were analyzed for the entire unmatched cohort and compared between the two matched cohorts using Student’s two-tailed t-test. P-value of < 0.05 was considered statistically significant, and a 10-point difference between mean scores was considered clinically meaningful.
Results
A total of 64 APBI patients were matched with 99 WBRT patients out of the entire study cohort of 320 cases. QOL scores for functional scales of QLQ-C30 were similar between the two groups for both matched and unmatched cohorts, while symptom scores of QLQ-C30 did not show any clinically significant difference. Functional scales of BR-23 did not show any clinical or statistically significant difference. Among symptom scales of BR-23, scores were similar for APBI and WBRT groups except for a worse score of “upset by hair loss” sub-scale in the brachytherapy group of the matched cohort (51.9 vs. 22.7, p = 0.006).
Conclusions
Patients undergoing APBI reported similar QOL compared to WBRT when matched for various factors.
中文翻译：
间质部分乳房近距离放射治疗和外束全乳放疗患者报告的生活质量：使用倾向评分匹配的比较
引言
本研究的目的是比较使用间质近距离放射治疗与外照射全乳放疗 (WBRT) 进行加速部分乳房照射 (APBI) 后患者报告的生活质量 (QOL) 评分。
材料与方法
这项前瞻性研究招募了在保乳手术后接受 WBRT 或 APBI 治疗的乳腺癌女性。使用 EORTC QLQ-C30 和 BR-23 问卷进行单一横断面 QOL 评估。接受 APBI 治疗的患者的倾向评分与接受 WBRT 治疗的类似患者队列相匹配。分析了整个不匹配队列的 QOL 分数，并使用学生的双尾 t 检验在两个匹配的队列之间进行比较。P 值 < 0.05 被认为具有统计学意义，平均分数之间的 10 分差异被认为具有临床意义。
结果
在整个 320 例研究队列中，共有 64 名 APBI 患者与 99 名 WBRT 患者相匹配。QLQ-C30 功能量表的 QOL 评分在匹配和非匹配队列中两组之间相似，而 QLQ-C30 的症状评分没有显示任何临床显着差异。BR-23 的功能量表没有显示出任何临床或统计学上的显着差异。在 BR-23 的症状量表中，APBI 和 WBRT 组的得分相似，但匹配队列的近距离放射治疗组的“脱发不安”子量表得分较差（51.9 对 22.7，p = 0.006）。
结论
在各种因素匹配时，接受 APBI 的患者报告的 QOL 与 WBRT 相似。
更新日期：2021-08-27
The aim of this study was to compare patient-reported quality of life (QOL) scores after accelerated partial breast irradiation (APBI) using interstitial brachytherapy vs. external beam whole breast radiotherapy (WBRT) for breast cancer.
Material and methods
Women with breast cancer treated with WBRT or APBI after breast conservation surgery were enrolled in this prospective study. Single cross-sectional QOL assessment was performed using EORTC QLQ-C30 and BR-23 questionnaires. Patients treated with APBI were propensity-score matched to similar cohort of patients treated with WBRT. QOL scores were analyzed for the entire unmatched cohort and compared between the two matched cohorts using Student’s two-tailed t-test. P-value of < 0.05 was considered statistically significant, and a 10-point difference between mean scores was considered clinically meaningful.
Results
A total of 64 APBI patients were matched with 99 WBRT patients out of the entire study cohort of 320 cases. QOL scores for functional scales of QLQ-C30 were similar between the two groups for both matched and unmatched cohorts, while symptom scores of QLQ-C30 did not show any clinically significant difference. Functional scales of BR-23 did not show any clinical or statistically significant difference. Among symptom scales of BR-23, scores were similar for APBI and WBRT groups except for a worse score of “upset by hair loss” sub-scale in the brachytherapy group of the matched cohort (51.9 vs. 22.7, p = 0.006).
Conclusions
Patients undergoing APBI reported similar QOL compared to WBRT when matched for various factors.
中文翻译：
间质部分乳房近距离放射治疗和外束全乳放疗患者报告的生活质量：使用倾向评分匹配的比较
引言
本研究的目的是比较使用间质近距离放射治疗与外照射全乳放疗 (WBRT) 进行加速部分乳房照射 (APBI) 后患者报告的生活质量 (QOL) 评分。
材料与方法
这项前瞻性研究招募了在保乳手术后接受 WBRT 或 APBI 治疗的乳腺癌女性。使用 EORTC QLQ-C30 和 BR-23 问卷进行单一横断面 QOL 评估。接受 APBI 治疗的患者的倾向评分与接受 WBRT 治疗的类似患者队列相匹配。分析了整个不匹配队列的 QOL 分数，并使用学生的双尾 t 检验在两个匹配的队列之间进行比较。P 值 < 0.05 被认为具有统计学意义，平均分数之间的 10 分差异被认为具有临床意义。
结果
在整个 320 例研究队列中，共有 64 名 APBI 患者与 99 名 WBRT 患者相匹配。QLQ-C30 功能量表的 QOL 评分在匹配和非匹配队列中两组之间相似，而 QLQ-C30 的症状评分没有显示任何临床显着差异。BR-23 的功能量表没有显示出任何临床或统计学上的显着差异。在 BR-23 的症状量表中，APBI 和 WBRT 组的得分相似，但匹配队列的近距离放射治疗组的“脱发不安”子量表得分较差（51.9 对 22.7，p = 0.006）。
结论
在各种因素匹配时，接受 APBI 的患者报告的 QOL 与 WBRT 相似。
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