During the last decades there has been a progressive increase in proportion of incidence of oral cancer not related to a known etiologic factor, such as the so-called “oral cancer in young”, a relevant tumor in non-smoker non-drinker (NSND) patients. The topic is matter of long standing debate, and adequate study models to analyze this entity are lacking.

Spontaneous oral cancer in companion animals such as dogs and cats, presents more clinical and biological similarities with the human oral cancer than any other animal model. In our review we analyze how the study of spontaneous oral cancer in common pets can prospectively prove to be of double usefulness in unraveling the question about the origin of oral cancer in NSND patients, allowing both the analysis of environmental and behavioral risk factors, and the study of how carcinogenic viruses, chronic inflammation, and changes in immunity can influence pre-tumoral and tumoral microenvironment.

在过去的几十年中，与已知病因无关的口腔癌发病率的比例逐渐增加，例如所谓的“年轻人口腔癌”，非吸烟者非饮酒者（NSND）中的相关肿瘤） 耐心。这个话题是长期争论的问题，缺乏足够的研究模型来分析这个实体。

伴侣动物（如狗和猫）的自发性口腔癌与人类口腔癌的临床和生物学相似性比任何其他动物模型都要多。在我们的综述中，我们分析了对普通宠物自发性口腔癌的研究如何前瞻性地证明在解开 NSND 患者口腔癌起源问题方面具有双重作用，既可以分析环境和行为风险因素，也可以分析研究致癌病毒、慢性炎症和免疫变化如何影响肿瘤前和肿瘤微环境。