State-of-play for cellular therapies in cardiac repair and regeneration,STEM CELLS

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State-of-play for cellular therapies in cardiac repair and regeneration
STEM CELLS ( IF 4.0 ) Pub Date : 2021-08-27 , DOI: 10.1002/stem.3446
Ramana Vaka ₁ , Darryl R Davis ₁

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Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ongoing clinical trials. Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of long-term cardiac engraftment. This discussion informs on promising new approaches to indicate future avenues for the field.

中文翻译：

细胞疗法在心脏修复和再生方面的最新进展

心血管疾病是全世界死亡的主要原因。近二十年来，细胞疗法一直被提议作为心脏病的解决方案。在本文中，我们报告了用于心脏修复和再生的细胞疗法的“现状”。我们概述了从临床前文献到正在进行的临床试验的新想法的进展。支持肌源性和旁分泌疗法的力学和机制的最新数据在长期心脏移植的背景下进行了评估。该讨论为有希望的新方法提供了信息，以表明该领域的未来途径。

更新日期：2021-08-27

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