In this paper, MPDA@hydroxyapatite nanocomposites (MPHA NCs) were prepared and applied to develop a novel reactive oxygen species (ROS)-triggered nitric oxide (NO)-enhanced photothermal therapy nanocomposite system composed of indocyanine green (ICG)/L-arginine-MPDA@HAp (AI-MPHA NCs) for displaying both NO gas therapy and photothermal osteosarcoma treatment. The nanosystem exhibited a mesoporous and core–shell structure and high ICG loading efficiency (about 90%). Under near infrared (NIR) irradiation, the AI-MPHA NCs could not only produce heat but also generate reactive oxygen species (ROS), inducing the catalysis of L-Arg to obtain NO. Under NIR irradiation, the AI-MPHA NCs achieved osteosarcoma ablation by a synergistic combination of photothermal therapy and NO-gas therapy. Additionally, the cell viability of MG-63 cells decreased to 23.6% (co-incubated with AI-MPHA NCs) under irradiation with a power density at 1.0 W cm⁻² for 10 min. The study proposed a novel nano-platform for NO-enhanced photothermal therapy of osteosarcoma.

中文翻译：

---

介孔聚多巴胺涂层羟基磷灰石纳米复合材料用于 ROS 触发的一氧化氮增强光热治疗骨肉瘤

在本文中，制备MPDA@羟基磷灰石纳米复合材料（MPHA NCs）并应用于开发由吲哚菁绿（ICG）/L-精氨酸组成的新型活性氧（ROS）触发的一氧化氮（NO）增强光热治疗纳米复合系统-MPDA@HAp (AI-MPHA NCs) 用于展示 NO 气体治疗和光热骨肉瘤治疗。该纳米系统表现出介孔和核壳结构和高ICG负载效率（约90%）。在近红外（NIR）照射下，AI-MPHA NCs不仅可以产生热量，还可以产生活性氧（ROS），诱导L-Arg催化获得NO。在 NIR 照射下，AI-MPHA NCs 通过光热疗法和 NO 气体疗法的协同组合实现了骨肉瘤消融。此外，MG-63 细胞的细胞活力降至 23。^-2 10 分钟。该研究提出了一种新型纳米平台，用于一氧化氮增强的骨肉瘤光热治疗。