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Immunotherapy of tumors by tailored nano-zeolitic imidazolate framework protected biopharmaceuticals
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-13 , DOI: 10.1039/d1bm01161h
Saikat Dutta 1
Affiliation  

In cancer immunotherapy, antibodies have acquired rapidly increasing attention due to their sustained immune effect by target specific delivery without any adverse effects. Among many recent strategies, controlled delivery of monoclonal antibodies, check point inhibitor storage and tumor-specific targeted delivery have enabled biodegradable immunotherapeutic delivery via translation of tailored nano-zeolitic imidazolate frameworks (ZIFs) with encapsulated biopharmaceuticals. In addition, a robust antitumor immunity was developed by anti-programmed death ligand-1 (anti-PD-L1) antibody delivery by ZIF-8 with polyethylene glycol (PEG) protection by forming a multiple immunoregulatory system. The unique biorecognition capability of antibodies, encapsulated in ZIFs, was recognized by using growth on different substrates, such as bioconjugates on gold nanorods, to transform them into plasmonic nanobiosensors with sensitivity of the refractive index profile of surface plasmons to track the conjugating antibody. Herein, we have discussed the mechanistic window of antibody delivery-based immunotherapy via the encapsulation of antibodies within ZIFs as an emerging tool for protecting biopharmaceuticals from the complex cellular microenvironment and hyperthermia to enable an antitumor immune response. To fully achieve the potential of antibodies upon ZIF encapsulation, more endeavors should be undertaken in the biodegradable engineering of ZIF-surfaces via forming cellular or polymeric layers to gain higher in vivo circulation time without inhibiting endocytosis by tumor cells. The possible future prognosis for achieving ZIF-protected biocompatible and biodegradable immunotherapeutic antibody delivery systems of therapeutic significance is discussed.

中文翻译:

通过定制的纳米沸石咪唑酯骨架保护的生物药物对肿瘤进行免疫治疗

在癌症免疫治疗中,抗体由于其通过靶向特异性递送的持续免疫作用而获得迅速增加的关注,并且没有任何副作用。在最近的许多策略中,单克隆抗体的控制递送、检查点抑制剂储存和肿瘤特异性靶向递送使可生物降解的免疫治疗递送通过用封装的生物药物翻译定制的纳米沸石咪唑酯骨架(ZIF)。此外,通过形成多重免疫调节系统,ZIF-8 在聚乙二醇 (PEG) 保护下递送抗程序性死亡配体-1 (anti-PD-L1) 抗体,开发了强大的抗肿瘤免疫。封装在 ZIF 中的抗体的独特生物识别能力是通过使用不同基质上的生长来识别的,例如金纳米棒上的生物共轭物,将它们转化为具有表面等离子体激元折射率分布敏感性的等离子体纳米生物传感器,以跟踪共轭抗体。在这里,我们已经讨论了抗体出货为主免疫治疗的机理窗口通过将抗体封装在 ZIF 中作为一种新兴工具,可保护生物药物免受复杂细胞微环境和高温的影响,从而实现抗肿瘤免疫反应。为了在 ZIF 封装后充分发挥抗体的潜力,应在 ZIF 表面的生物可​​降解工程中进行更多的努力,通过形成细胞或聚合物层来获得更长的体内循环时间而不抑制肿瘤细胞的内吞作用。讨论了实现具有治疗意义的 ZIF 保护的生物相容性和可生物降解的免疫治疗性抗体递送系统的可能未来预后。
更新日期:2021-08-27
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