Caveolin-1 (Cav-1) is a structural protein component of caveolae, which are invaginations of the plasma membrane involved in various cellular processes, including endocytosis, extracellular matrix organization, cholesterol distribution, cell migration and signaling. Mounting evidence over the last 10-15 years has demonstrated a central role of Cav-1 in many diseases, such as cancer, diabetes and fibrosis. Cav-1 plays positive and negative roles in various diseases through its different regulation pathways. Here, we review the current knowledge on Cav-1 in different diseases and discuss the role of this protein in human organs and diseases.

中文翻译：

---

Caveolin-1 在人体器官功能和疾病中的作用：朋友还是敌人？

Caveolin-1 (Cav-1) 是小窝的一种结构蛋白成分，它是质膜的内陷，参与各种细胞过程，包括内吞作用、细胞外基质组织、胆固醇分布、细胞迁移和信号传导。过去 10-15 年越来越多的证据表明 Cav-1 在癌症、糖尿病和纤维化等许多疾病中的核心作用。Cav-1通过其不同的调控途径在各种疾病中发挥正负作用。在这里，我们回顾了当前关于 Cav-1 在不同疾病中的知识，并讨论了这种蛋白质在人体器官和疾病中的作用。