SARS-CoV-2 has a disproportionately severe effect on men, suggesting that the androgen pathway plays a role in the disease. Studies on the effect of castration and androgen receptor (AR) blockade have been mixed, while 5α-reductase inhibitor (5ARI) use in men with COVID-19 have shown potential benefits. We assessed the association of 5ARI use on risk of community acquired SARS-CoV-2 infection.

中文翻译：

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5α-还原酶抑制剂与降低 SARS-COV-2 感染风险有关：基于注册的配对分析。

SARS-CoV-2 对男性的影响不成比例，这表明雄激素途径在该疾病中起作用。关于去势和雄激素受体 (AR) 阻断作用的研究混杂在一起，而 5α-还原酶抑制剂 (5ARI) 用于 COVID-19 男性患者已显示出潜在的益处。我们评估了 5ARI 使用与社区获得性 SARS-CoV-2 感染风险的关系。