Macromers, polymeric molecules with at least two functional groups for cross-polymerization, are interesting materials to tailor mechanical, biochemical and degradative bulk and surface properties of implants for tissue regeneration. In this review we focus on macromers with at least one biodegradable building block. Manifold design options, such as choice of polymeric block(s), optional core molecule and reactive groups, as well as cross-co-polymerization with suitable anchor or linker molecules, allow the adaptation of macromer-based biomaterials towards specific application requirements in both hard and soft tissue regeneration. Implants can be manufactured from macromers using additive manufacturing as well as molding and templating approaches. This review summarizes and discusses the overall concept of biodegradable macromers and recent approaches for macromer processing into implants as well as techniques for surface modification directed towards bone regeneration. These aspects are reviewed including a focus on the authors’ contributions to the field through research within the collaborative research project Transregio 67.

中文翻译：

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用于植入体和表面工程的可生物降解大分子单体

大分子单体是具有至少两个用于交叉聚合的官能团的聚合物分子，是一种有趣的材料，可用于定制用于组织再生的植入物的机械、生化和降解体积和表面特性。在这篇综述中，我们重点关注具有至少一种可生物降解结构单元的大分子单体。歧管设计选项，例如选择聚合物嵌段、可选的核心分子和反应基团，以及与合适的锚或连接分子的交叉共聚，允许基于大分子单体的生物材料适应两者的特定应用要求硬组织和软组织再生。植入物可以使用增材制造以及成型和模板方法从大分子单体制造。这篇综述总结并讨论了可生物降解的大分子单体的总体概念和最近将大分子单体加工成植入物的方法，以及针对骨再生的表面改性技术。回顾了这些方面，包括通过合作研究项目 Transregio 67 中的研究，重点关注作者对该领域的贡献。