In the present study, we aimed to estimate the impact of hypertension in the working-age Japanese population. We developed life table models to estimate total deaths, years of life lived, and productivity-adjusted life years lived (a newly developed metric for quantifying the burden of acute and chronic health conditions on work productivity) among Japanese individuals with hypertension aged 20–64 years, with simulated follow-up until age 65 years. Data inputs were drawn from local population statistics and published sources. Gross domestic product per person employed, a measure of labor productivity, was used to assign an economic value to each productivity-adjusted life year lived. Outcomes and costs were discounted by 2% annually. In 2017, 26.3 million Japanese individuals aged 20–64 years (37.5%) had hypertension. Of these people, 23.7% were treated and had controlled blood pressure, 23.2% were treated but had uncontrolled blood pressure, and 53.1% were untreated. During the simulated follow-up until age 65 years, 335,342 deaths (28.0% of total deaths), 1.6 million years of life (0.8% of total), 3.1 million productivity-adjusted life years (1.9% of total), and US$242.9 billion or 28.3 trillion Japanese yen of gross domestic product were lost to hypertension. Our findings highlight the considerable economic burden of hypertension in Japan, as well as the importance of effective strategies for hypertension prevention and management, which are likely to deliver a significant return on investment.

在本研究中，我们旨在评估高血压对日本工作年龄人口的影响。我们开发了生命表模型来估计日本 20-64 岁高血压患者的总死亡人数、寿命年数和生产力调整寿命年数（一种新开发的指标，用于量化急性和慢性健康状况对工作生产力的负担）年，模拟随访至 65 岁。数据输入来自当地人口统计数据和公布的来源。人均国内生产总值是劳动生产率的一种衡量标准，用于为每个经过生产率调整的生命年分配经济价值。结果和成本每年折现 2%。2017 年，2630 万日本 20-64 岁的人（37.5%）患有高血压。在这些人中，有 23 人。7% 接受治疗并控制了血压，23.2% 接受治疗但血压未控制，53.1% 未接受治疗。在直至 65 岁的模拟随访期间，335,342 人死亡（占总死亡人数的 28.0%）、160 万年生命（占总数的 0.8%）、310 万生产力调整生命年（占总数的 1.9%）和 242.9 美元10 亿或 28.3 万亿日元的国内生产总值因高血压而损失。我们的研究结果强调了日本高血压的巨大经济负担，以及有效的高血压预防和管理策略的重要性，这些策略可能会带来可观的投资回报。342 人死亡（占总死亡人数的 28.0%）、160 万年生命（占总死亡人数的 0.8%）、310 万生产力调整生命年（占总死亡人数的 1.9%）以及 2429 亿美元或 28.3 万亿日元的国内生产总值输给了高血压。我们的研究结果强调了日本高血压的巨大经济负担，以及有效的高血压预防和管理策略的重要性，这些策略可能会带来可观的投资回报。342 人死亡（占总死亡人数的 28.0%）、160 万年生命（占总死亡人数的 0.8%）、310 万生产力调整生命年（占总死亡人数的 1.9%）以及 2429 亿美元或 28.3 万亿日元的国内生产总值输给了高血压。我们的研究结果强调了日本高血压的巨大经济负担，以及有效的高血压预防和管理策略的重要性，这些策略可能会带来可观的投资回报。