Dairy goats play a significant role in socio-economic, cultural, and nutritional development in many countries. This study aimed to identify multiresistant zoonotic pathogens causing mastitis in goats, in addition to characterizing them for the presence of resistance genes and phenotypic resistance. A total of 714 milk samples from 357 lactating goats in 12 farms in the Northeast region of Brazil were analyzed. The isolates were submitted to Matrix Associated Laser Desorption-Ionization - Time of Flight to identify bacterial species, Polymerase Chain Reaction (PCR) to search for resistance genes, and an antibiogram to evaluate the phenotypic profile of antimicrobial resistance. A total of 214 pathogens were identified and bacterial prevalence was 83.29 % (178/214) Staphylococcus spp.; 6.50 % (14/214) Micrococcus luteus; 3.73 % (8/214) Corynebacterium spp.; 2.80 % (6/214) Bacillus spp.; 1.38 % (3/214) Escherichia coli; 0.92 % (2/214) Enterobacter cloacae; 0.46 % (1/214) Aerococcus viridans; 0.46 % (1/214) Morganella morganii; and 0.46 % (1/214) Turicella otitidis. As for gene frequency, 64.60 % (115/178) of the isolates carried the blaZ gene; 37.07 % (66/178) norA; 22.47 % (40/178) tet(L); 16.85 % (30/178) tet(M); 14.04 % (25/178) norB; 8.42 % (15/178) vanA; 7.30 % (13/178) msrA; 6.41 % (5/178) tet-38; 4.49 % (8/178) norC; 2.25 % (4/178) mecA; and 0.56 % (1/178) vanB. Emerging multiresistant zoonotic pathogens are present in the goat milk production chain, especially the coagulase-negative Staphylococcus species that pose a risk to human and animal health.

奶山羊在许多国家的社会经济、文化和营养发展中发挥着重要作用。本研究旨在鉴定引起山羊乳腺炎的多重抗性人畜共患病病原体，此外还对它们的抗性基因和表型抗性进行表征。分析了来自巴西东北部地区 12 个农场的 357 只泌乳山羊的 714 份牛奶样品。将分离株提交给基质相关激光解吸电离 - 飞行时间以识别细菌种类，聚合酶链反应 (PCR) 以搜索抗性基因，并提交抗生素图以评估抗菌素耐药性的表型特征。共鉴定出 214 种病原体，细菌流行率为 83.29 % (178/214)葡萄球菌；6.50 % (14/214)藤黄微球菌；3.73 % (8/214)棒状杆菌属；2.80 % (6/214)芽孢杆菌；1.38 % (3/214)大肠杆菌；0.92 % (2/214)阴沟肠杆菌；0.46 % (1/214)绿色气球菌；0.46 % (1/214)摩根氏菌；和 0.46 % (1/214)耳炎耳炎。至于基因频率，64.60%（115/178）的分离株携带blaZ基因；37.07％（178分之66）NORA ; 22.47 % (40/178) tet (L)；16.85 % (30/178) tet (M)；14.04％（178分之25）NORB ; 8.42% (15/178) vanA；7.30 % (13/178)msrA ; 6.41 % (5/178) tet -38；4.49 % (8/178)北卡罗来纳州；2.25 % (4/178) mecA；和 0.56% (1/178) vanB。山羊奶生产链中存在新出现的多重抗性人畜共患病原体，尤其是对人类和动物健康构成风险的凝固酶阴性葡萄球菌。