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Macro-microporous zeolitic imidazole framework-8/cellulose aerogel for semi-automated pipette tip solid phase extraction of fluoroquinolones in water
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2021-08-25 , DOI: 10.1016/j.aca.2021.338984
Lin Li 1 , Hongyu Zhang 1 , Qian Zhang 1 , Ting Wang 2 , Xiaohong Hou 2
Affiliation  

In this study, Zeolitic Imidazole Framework-8/cellulose aerogel (ZIF-8/CA) hybrid was successfully fabricated through a simple doping method and ZIF-8 acted as the major component for adsorption. In order to elucidate the adsorption mechanism deeply, molecular simulation was adopted to the expound the interaction modes between ZIF-8 and the fluoroquinolones (FQs). ZIF-8/CA was used as the adsorbent for semi-automated pipette tip solid phase extraction (PT-SPE). In combination with high performance liquid chromatography tandem fluorescence detector (HPLC-FLD), the established method was successfully employed to determine trace amount of FQs in water samples. Extraction parameters such as the content of ZIF-8, pH of sample solution, volume of sample, flow rate of sampling, type and volume of elution solvent were investigated. Under the optimized conditions, satisfactory linearity was achieved with the correlation coefficient (R2) ranging from 0.9954 to 0.9992. The limits of detection were in the range of 0.337–1.707 ng L−1. And the recoveries varied from 75.9% to 96.8% with RSD less than 8.0%. The established method was demonstrated to be sensitive, efficient and convenient.



中文翻译:

用于半自动移液管吸头固相萃取水中氟喹诺酮类药物的大微孔沸石咪唑骨架-8/纤维素气凝胶

在本研究中,沸石咪唑骨架-8/纤维素气凝胶(ZIF-8/CA)杂化物通过简单的掺杂方法成功制备,ZIF-8作为吸附的主要成分。为了深入阐明吸附机理,采用分子模拟方法阐述了ZIF-8与氟喹诺酮类药物(FQs)的相互作用模式。ZIF-8/CA 用作半自动移液管吸头固相萃取 (PT-SPE) 的吸附剂。结合高效液相色谱串联荧光检测器(HPLC-FLD),所建立的方法成功地用于测定水样中的痕量FQs。考察了ZIF-8的含量、样品溶液的pH值、样品体积、进样流速、洗脱溶剂的类型和体积等提取参数。2 ) 范围从 0.9954 到 0.9992。检测限在 0.337–1.707 ng L -1的范围内。回收率从 75.9% 到 96.8% 不等,RSD 小于 8.0%。所建立的方法被证明是灵敏、高效和方便的。

更新日期:2021-09-15
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