In this study, Zeolitic Imidazole Framework-8/cellulose aerogel (ZIF-8/CA) hybrid was successfully fabricated through a simple doping method and ZIF-8 acted as the major component for adsorption. In order to elucidate the adsorption mechanism deeply, molecular simulation was adopted to the expound the interaction modes between ZIF-8 and the fluoroquinolones (FQs). ZIF-8/CA was used as the adsorbent for semi-automated pipette tip solid phase extraction (PT-SPE). In combination with high performance liquid chromatography tandem fluorescence detector (HPLC-FLD), the established method was successfully employed to determine trace amount of FQs in water samples. Extraction parameters such as the content of ZIF-8, pH of sample solution, volume of sample, flow rate of sampling, type and volume of elution solvent were investigated. Under the optimized conditions, satisfactory linearity was achieved with the correlation coefficient (R²) ranging from 0.9954 to 0.9992. The limits of detection were in the range of 0.337–1.707 ng L⁻¹. And the recoveries varied from 75.9% to 96.8% with RSD less than 8.0%. The established method was demonstrated to be sensitive, efficient and convenient.

在本研究中，沸石咪唑骨架-8/纤维素气凝胶（ZIF-8/CA）杂化物通过简单的掺杂方法成功制备，ZIF-8作为吸附的主要成分。为了深入阐明吸附机理，采用分子模拟方法阐述了ZIF-8与氟喹诺酮类药物（FQs）的相互作用模式。ZIF-8/CA 用作半自动移液管吸头固相萃取 (PT-SPE) 的吸附剂。结合高效液相色谱串联荧光检测器（HPLC-FLD），所建立的方法成功地用于测定水样中的痕量FQs。考察了ZIF-8的含量、样品溶液的pH值、样品体积、进样流速、洗脱溶剂的类型和体积等提取参数。² ) 范围从 0.9954 到 0.9992。检测限在 0.337–1.707 ng L ^-1的范围内。回收率从 75.9% 到 96.8% 不等，RSD 小于 8.0%。所建立的方法被证明是灵敏、高效和方便的。