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Graphene nanopore devices for DNA sequencing: A tight-binding model study
Physica B: Condensed Matter ( IF 2.8 ) Pub Date : 2021-08-26 , DOI: 10.1016/j.physb.2021.413334
Sourav Kundu 1 , S.N. Karmakar 2
Affiliation  

We present a tight-binding model study of a two-terminal graphene nanopore device for sequential determination of DNA bases. Using Green’s function technique we investigate the changes in electronic transport properties of the device due to insertion of different nucleotides into the nanopore created within a zigzag graphene nanoribbon. First we try to characterize the device in static condition and then go for sequencing application by setting the bias across it to a specific voltage and then recording the characteristic current signals corresponding to each nucleotides of a translocating DNA. Our investigations show that graphene nanopores can certainly become very efficient and reliable for sequencing applications in future.



中文翻译:

用于 DNA 测序的石墨烯纳米孔装置:紧密结合模型研究

我们提出了一种用于连续测定 DNA 碱基的两端石墨烯纳米孔装置的紧密结合模型研究。使用格林函数技术,我们研究了由于将不同的核苷酸插入在锯齿形石墨烯纳米带内产生的纳米孔中而导致的器件电子传输特性的变化。首先,我们尝试在静态条件下表征设备,然后通过将其两端的偏置设置为特定电压,然后记录与易位 DNA 的每个核苷酸对应的特征电流信号来进行测序应用。我们的研究表明,石墨烯纳米孔在未来的测序应用中肯定会变得非常高效和可靠。

更新日期:2021-09-03
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