The intensive use of the antihypertensive losartan potassium (LOS) has culminated in its high occurrence in aquatic environments. However, insufficient studies had investigated its effects in non-target organisms. In this study, ecotoxicity of LOS was assessed in aquatic organisms from distinct trophic levels (Desmodesmus subspicatus, Daphnia magna, and Astyanax altiparanae). Genotoxicity was assessed by the comet assay in D. magna and A. altiparanae, and biochemical biomarkers for the fish. LOS was more toxic to D. subspicatus (EC_50(72h) = 27.93 mg L⁻¹) than D. magna (EC₅₀ = 303.69 mg L⁻¹). Subsequently, this drug showed to induce more DNA damage in D. magna than A. altiparanae, when exposed to 2.5 mg L⁻¹. No significant stress responses were observed by the fish biomarkers, suggesting that higher trophic levels organisms are more tolerant to LOS toxicity. LOS showed relatively low toxic potential for a short period of exposure, but with different patterns of toxicity for the organisms from distinct trophic levels, contributing to further risk assessment of LOS.

抗高血压氯沙坦钾 (LOS) 的大量使用导致其在水生环境中的高发生率。然而，没有足够的研究调查其对非目标生物的影响。在这项研究中，对来自不同营养级的水生生物（Desmodesmus subspicatus、Daphnia magna和Astyanax altiparanae）评估了 LOS 的生态毒性。遗传毒性通过D. magna和A. altiparanae 中的彗星试验以及鱼的生化生物标志物进行评估。LOS 对D. subspicatus (EC _50(72h) = 27.93 mg L ^-1 ) 的毒性大于D. magna (EC ₅₀ = 303.69 mg L ^-1）。随后，当暴露于 2.5 mg L ^-1时，该药物显示在D. magna 中比A. altiparanae诱导更多的 DNA 损伤。鱼类生物标志物未观察到显着的应激反应，表明较高营养水平的生物对 LOS 毒性更耐受。LOS 在短期暴露内表现出相对较低的毒性潜力，但对来自不同营养水平的生物体具有不同的毒性模式，有助于进一步评估 LOS 的风险。