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The immunological link between neonatal lung and eye disease
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-08-25 , DOI: 10.1002/cti2.1322 Lakshanie C Wickramasinghe 1 , Peter van Wijngaarden 2, 3 , Evelyn Tsantikos 1 , Margaret L Hibbs 1
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-08-25 , DOI: 10.1002/cti2.1322 Lakshanie C Wickramasinghe 1 , Peter van Wijngaarden 2, 3 , Evelyn Tsantikos 1 , Margaret L Hibbs 1
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Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are two neonatal diseases of major clinical importance, arising in large part as a consequence of supplemental oxygen therapy used to promote the survival of preterm infants. The presence of coincident inflammation in the lungs and eyes of neonates receiving oxygen therapy indicates that a dysregulated immune response serves as a potential common pathogenic factor for both diseases. This review examines the current state of knowledge of immunological dysregulation in BPD and ROP, identifying similarities in the cellular subsets and inflammatory cytokines that are found in the alveoli and retina during the active phase of these diseases, indicating possible mechanistic overlap. In addition, we highlight gaps in the understanding of whether these responses emerge independently in the lung and retina as a consequence of oxygen exposure or arise because of inflammatory spill-over from the lung. As BPD and ROP are anatomically distinct, they are often considered discreet disease entities and are therefore treated separately. We propose that an improved understanding of the relationship between BPD and ROP is key to the identification of novel therapeutic targets to treat or prevent both conditions simultaneously.
中文翻译：
新生儿肺病和眼病之间的免疫学联系
支气管肺发育不良（BPD）和早产儿视网膜病变（ROP）是两种具有重要临床意义的新生儿疾病，很大程度上是由于用于促进早产儿存活的补充氧疗的结果。接受氧疗的新生儿肺部和眼睛同时存在炎症，表明免疫反应失调是这两种疾病的潜在共同致病因素。本综述探讨了 BPD 和 ROP 免疫失调的当前知识状况，确定了这些疾病活跃期肺泡和视网膜中发现的细胞亚群和炎症细胞因子的相似性，表明可能存在机制重叠。此外，我们强调了对于这些反应是由于氧气暴露而在肺部和视网膜中独立出现还是由于肺部炎症溢出而出现的理解上的差距。由于 BPD 和 ROP 在解剖学上不同，因此它们通常被认为是谨慎的疾病实体，因此需要单独治疗。我们认为，更好地理解 BPD 和 ROP 之间的关系是确定同时治疗或预防这两种疾病的新治疗靶点的关键。
更新日期：2021-08-26
中文翻译：
新生儿肺病和眼病之间的免疫学联系
支气管肺发育不良（BPD）和早产儿视网膜病变（ROP）是两种具有重要临床意义的新生儿疾病，很大程度上是由于用于促进早产儿存活的补充氧疗的结果。接受氧疗的新生儿肺部和眼睛同时存在炎症，表明免疫反应失调是这两种疾病的潜在共同致病因素。本综述探讨了 BPD 和 ROP 免疫失调的当前知识状况，确定了这些疾病活跃期肺泡和视网膜中发现的细胞亚群和炎症细胞因子的相似性，表明可能存在机制重叠。此外，我们强调了对于这些反应是由于氧气暴露而在肺部和视网膜中独立出现还是由于肺部炎症溢出而出现的理解上的差距。由于 BPD 和 ROP 在解剖学上不同，因此它们通常被认为是谨慎的疾病实体，因此需要单独治疗。我们认为，更好地理解 BPD 和 ROP 之间的关系是确定同时治疗或预防这两种疾病的新治疗靶点的关键。
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