The combination (TA/MWCNTs) of tannic acid decorated with carbon nanotubes was prepared to build a new electrochemical sensor to detect the clozapine (Clp). Scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques were used to characterize the morphological and electrochemical changes of the platform (TA/MWCNTs/GCE) obtained by modifying the glassy carbon electrode with the TA/MWCNTs combination. The active surface areas of the bare GCE and TA/MWCNTs/GCE were found to be 0.124 cm² and 0.340 cm², respectively. TA/MWCNTs/GCE surface exhibited a well-defined redox couple for Clp at 0.42 V and 0.36 V in pH 8.0. phosphate buffer solution. Under optimum conditions, the peak currents of square wave voltammograms of Clp with a detection limit of 0.55 nM and a quantification limit of 1.67 nM showed a linear increase at the 0.05 µM ~ 0.375 µM interval. The proposed TA/MWCNTs/GCE platform exhibited good repeatability, high sensitivity and excellent accuracy for Clp. The proposed platform was successfully applied for the quantification of Clp in pharmaceutical, serum and urine samples. Such precise quantification of Clp makes it important and interesting for monitoring the therapeutic use of the proposed platform.

准备用碳纳米管装饰的单宁酸的组合（TA/MWCNTs）构建一种新的电化学传感器来检测氯氮平（Clp）。扫描电子显微镜 (SEM) 和循环伏安法 (CV) 技术用于表征通过用 TA/MWCNTs 组合改性玻璃碳电极获得的平台 (TA/MWCNTs/GCE) 的形态和电化学变化。发现裸 GCE 和 TA/MWCNTs/GCE 的活性表面积分别为 0.124 cm ²和 0.340 cm ²， 分别。TA/MWCNTs/GCE 表面在 0.42 V 和 0.36 V 的 pH 值下对 Clp 表现出明确定义的氧化还原对。磷酸盐缓冲溶液。在最佳条件下，检测限为 0.55 nM 和定量限为 1.67 nM 的 Clp 方波伏安图的峰值电流在 0.05 µM ~ 0.375 µM 区间呈线性增加。所提出的 TA/MWCNTs/GCE 平台对 Clp 表现出良好的重复性、高灵敏度和出色的准确性。所提出的平台已成功应用于药物、血清和尿液样品中 Clp 的定量分析。Clp 的这种精确量化使得监测所提议平台的治疗用途变得重要和有趣。