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Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans
Journal of Biomechanics ( IF 2.4 ) Pub Date : 2021-08-26 , DOI: 10.1016/j.jbiomech.2021.110707
Lauren N Heckelman 1 , Benjamin R Wesorick 1 , Louis E DeFrate 2 , Richard H Lee 3
Affiliation  

Hip fractures are a significant burden on the aging population, often resulting in reduced mobility, loss of independence, and elevated risk of mortality. While fracture risk is generally inversely related to bone mineral density (BMD), people with diabetes suffer a higher fracture rate despite having a higher BMD. To better understand the connection between diabetes and fracture risk, we developed a method to measure the minimum moment of inertia (mMOI; a geometric factor associated with fracture risk) from clinical CT scans of the pelvis. Since hip fractures are more prevalent in women, we focused on females in this study. We hypothesized that females with diabetes would have a lower mMOI along the femoral neck than those without diabetes, indicative of a higher fracture risk. Three-dimensional models of each hip were created from clinical CT scans of 40 older women (27 with diabetes: 10 fracture/17 non-fractured; 13 without diabetes: non-fractured controls). The mMOI of each hip (n = 80) was reported as the average from three trials. People with diabetes had an 18% lower mMOI as compared to those without diabetes after adjusting for age and BMI (p = 0.02). No differences in the mMOIs between the fractured and contralateral hips in the diabetic group were observed (p = 0.78). Similarly, no differences were observed between the fractured and non-fractured hips of people with diabetes (p = 0.29) when accounting for age and BMI. This suggests structural differences in the hips of individuals with diabetes (measured by the mMOI) may be associated with their elevated fracture risk.



中文翻译:

糖尿病与老年女性较低的最小惯性矩有关:临床 CT 扫描的 3D 重建分析

髋部骨折是老年人口的一个重大负担,通常会导致行动不便、丧失独立性和死亡风险升高。虽然骨折风险通常与骨矿物质密度 (BMD) 成反比,但糖尿病患者尽管 BMD 较高,但骨折率较高。为了更好地了解糖尿病与骨折风险之间的联系,我们开发了一种方法来测量骨盆临床 CT 扫描的最小惯性矩(mMOI;与骨折风险相关的几何因素)。由于髋部骨折在女性中更为普遍,因此我们在本研究中重点关注女性。我们假设患有糖尿病的女性股骨颈的 mMOI 比没有糖尿病的女性低,这表明骨折风险更高。每个髋关节的三维模型是根据 40 名老年妇女的临床 CT 扫描创建的(27 名患有糖尿病:10 名骨折/17 名未骨折;13 名未患糖尿病:未骨折对照)。每个髋关节 (n = 80) 的 mMOI 被报告为三个试验的平均值。调整年龄和 BMI 后,糖尿病患者的 mMOI 比非糖尿病患者低 18% (p = 0.02)。未观察到糖尿病组骨折髋和对侧髋之间的 mMOI 存在差异 (p = 0.78)。同样,在考虑年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。10 例骨折/17 例未骨折;13 没有糖尿病:非骨折对照)。每个髋关节 (n = 80) 的 mMOI 被报告为三个试验的平均值。调整年龄和 BMI 后,糖尿病患者的 mMOI 比非糖尿病患者低 18% (p = 0.02)。未观察到糖尿病组骨折髋和对侧髋之间的 mMOI 存在差异 (p = 0.78)。同样,在考虑年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。10 例骨折/17 例未骨折;13 没有糖尿病:非骨折对照)。每个髋关节 (n = 80) 的 mMOI 被报告为三个试验的平均值。调整年龄和 BMI 后,糖尿病患者的 mMOI 比非糖尿病患者低 18% (p = 0.02)。未观察到糖尿病组骨折髋和对侧髋之间的 mMOI 存在差异 (p = 0.78)。同样,在考虑年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。调整年龄和 BMI 后,糖尿病患者的 mMOI 比非糖尿病患者低 18% (p = 0.02)。未观察到糖尿病组骨折髋和对侧髋之间的 mMOI 存在差异 (p = 0.78)。同样,在考虑年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。调整年龄和 BMI 后,糖尿病患者的 mMOI 比非糖尿病患者低 18% (p = 0.02)。未观察到糖尿病组骨折髋和对侧髋之间的 mMOI 存在差异 (p = 0.78)。同样,在考虑年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。当考虑到年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。当考虑到年龄和 BMI 时,糖尿病患者骨折和未骨折的髋关节之间没有差异 (p = 0.29)。这表明糖尿病患者髋部的结构差异(通过 mMOI 测量)可能与骨折风险升高有关。

更新日期:2021-09-04
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