UiO-66-NH₂ (U) and its magnetic UiO-66-NH₂ form (MU) were used to enhance Oxaliplatin (OX) efficacy. The fundamental physical and structural properties of nanoparticles were characterized via X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR), UV–Visible (UV–Vis), Brunauer–Emmett–Teller (BET) surface area analysis, field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray analysis (EDAX) and mapping, and Dynamic light scattering (DLS). The results further showed an improved anticancer activity and efficacy of the designed drug delivery systems (DDSs) compared to OX in 2-and 3-dimensional models of colorectal cancer in which cell viability, proliferation and migration, and morphology were assessed. Additionally, the oxidative/antioxidant activity of U and MU-loaded OX demonstrated greater oxidative behavior compared to OX. In vitro experiments showed that U and MU could inhibit the proliferation and migration of colorectal cancer cells in a dose-dependent manner. The half-maximal inhibitory concentration (IC₅₀) values were found to be 6.10 ppm for OX, 18.47 ppm for MU(OX), and 47.02 ppm for U(OX), respectively. The U(OX) and MU(OX) were more effective than OX in terms of drug release. The results indicate that U and MU show considerable promise as a novel and effective drug delivery system for the treatment of colorectal cancer and possibly other malignancies.

UiO-66-NH ₂ (U)及其磁性UiO-66-NH ₂形式 (MU) 用于增强奥沙利铂 (OX) 功效。通过 X 射线衍射 (XRD)、傅里叶变换红外 (FTIR)、紫外-可见 (UV-Vis)、Brunauer-Emmett-Teller (BET) 表面积分析、场发射扫描表征纳米颗粒的基本物理和结构特性电子显微镜 (FESEM)、能量色散 X 射线分析 (EDAX) 和映射，以及动态光散射 (DLS)。结果进一步表明，在评估细胞活力、增殖和迁移以及形态学的结直肠癌 2 维和 3 维模型中，与 OX 相比，设计的药物递送系统 (DDS) 的抗癌活性和功效有所提高。此外，与 OX 相比，载有 U 和 MU 的 OX 的氧化/抗氧化活性表现出更大的氧化行为。体外实验表明，U和MU能够以剂量依赖的方式抑制结直肠癌细胞的增殖和迁移。半数最大抑菌浓度（IC₅₀ ) 的值分别为 OX 6.10 ppm、MU(OX) 18.47 ppm 和 U(OX) 47.02 ppm。在药物释放方面，U(OX)和MU(OX)比OX更有效。结果表明，U 和 MU 作为治疗结直肠癌和可能的其他恶性肿瘤的新型有效药物递送系统显示出相当大的前景。