There is a pressing need to develop measures that are sensitive to the earliest subtle cognitive changes of Alzheimer's disease (AD) to improve early detection and track disease progression. The Loewenstein-Acevedo Scales of Semantic Interference (LASSI-L) has been shown to successfully discriminate between cognitively unimpaired (CU) older adults and those with amnestic mild cognitive impairment (MCI) and to correlate with total and regional brain amyloid load. The present study investigated how the LASSI-L scores change over time among three distinct diagnostic groups. Eighty-six community-dwelling older adults underwent a baseline evaluation including: a clinical interview, a neuropsychological evaluation, Magnetic Resonance Imaging (MRI), and amyloid Positron Emission Tomography (PET). A follow up evaluation was conducted 12 months later. Initial mean values were calculated using one-way ANOVAs and chi-square analyses. Post-hoc comparisons were conducted using Tukey's Honestly Significant Difference (HSD). A 3 × 2 repeated measures analysis was utilized to examine differences in LASSI-L performance over time. The MCI amyloid positive group demonstrated a significantly greater decline in LASSI-L performance than the MCI amyloid negative and CU groups respectively. The scales that best differentiated the three groups included the Cued A2, which taps into maximum learning capacity, and Cued B2, which assesses the failure to recover from proactive semantic interference. Our findings further support the LASSI-L's discriminative validity.

迫切需要开发对阿尔茨海默病 (AD) 最早的微妙认知变化敏感的措施，以改善早期检测并跟踪疾病进展。 Loewenstein-Acevedo 语义干扰量表 (LASSI-L) 已被证明可以成功地区分认知未受损 (CU) 的老年人和遗忘性轻度认知障碍 (MCI) 的老年人，并与大脑总淀粉样蛋白负荷和区域淀粉样蛋白负荷相关。本研究调查了三个不同诊断组的 LASSI-L 评分如何随时间变化。 86 名社区居住的老年人接受了基线评估，包括：临床访谈、神经心理学评估、磁共振成像 (MRI) 和淀粉样蛋白正电子发射断层扫描 (PET)。 12个月后进行了跟踪评估。使用单向方差分析和卡方分析计算初始平均值。使用 Tukey 的诚实显着差异 (HSD) 进行事后比较。采用 3 × 2 重复测量分析来检查 LASSI-L 性能随时间的差异。 MCI 淀粉样蛋白阳性组的 LASSI-L 性能下降分别比 MCI 淀粉样蛋白阴性组和 CU 组显着更大。最能区分这三组的量表包括 Cued A2（挖掘最大学习能力）和 Cued B2（评估从主动语义干扰中恢复的失败情况）。我们的研究结果进一步支持 LASSI-L 的区分有效性。