Synthesis of 1-Tri(di)fluoromethyl 1,4-Diketones Enabled by Radical Brook Rearrangement,European Journal of Organic Chemistry

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Synthesis of 1-Tri(di)fluoromethyl 1,4-Diketones Enabled by Radical Brook Rearrangement
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-08-25 , DOI: 10.1002/ejoc.202100860
Zhihong Zhu ₁ , Xiang Chen ₁ , Shanshan Liu ₁ , Jianjun Zhang ₂ , Xiao Shen ₃

Affiliation

The application of Mn-catalyzed radical Brook rearrangement of fluorinated organosilicon reagents in the synthesis of 1-trifluoromethyl and 1-difluoromethyl 1,4-diktones have been disclosed for the first time. The potential of this advance have been highlighted by the transformation of the products to biologically important fluoroalkylated heterocycles.