Low sun exposure acts synergistically with high Epstein−Barr nuclear antigen 1 (EBNA-1) antibody levels in multiple sclerosis etiology,European Journal of Neurology

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Low sun exposure acts synergistically with high Epstein−Barr nuclear antigen 1 (EBNA-1) antibody levels in multiple sclerosis etiology
European Journal of Neurology ( IF 4.5 ) Pub Date : 2021-08-26 , DOI: 10.1111/ene.15082
Anna Karin Hedström _{1,

2} , Jesse Huang ₂ , Nicole Brenner ₃ , Julia Butt ₃ , Ingrid Kockum ₂ , Tim Waterboer ₃ , Tomas Olsson ₂ , Lars Alfredsson _{1,

2,

4}

Affiliation

Among multiple sclerosis (MS) patients, an association has been observed between low levels of vitamin D and high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels. However, whether sun exposure/vitamin D moderates the role of Epstein-Barr virus (EBV) infection in MS etiology is unclear. We aimed to investigate potential synergistic effects between low sun exposure and elevated EBNA-1 antibody levels regarding MS risk.

中文翻译：

在多发性硬化症病因学中，低阳光照射与高 Epstein-Barr 核抗原 1 (EBNA-1) 抗体水平协同作用

在多发性硬化症 (MS) 患者中，已观察到低水平的维生素 D 和高水平的 Epstein-Barr 核抗原 1 (EBNA-1) 抗体水平之间存在关联。然而，日晒/维生素 D 是否会减轻 Epstein-Barr 病毒 (EBV) 感染在 MS 病因学中的作用尚不清楚。我们旨在研究低阳光照射和 EBNA-1 抗体水平升高之间关于 MS 风险的潜在协同效应。

更新日期：2021-08-26

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