How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes,ChemPhysChem

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How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes
ChemPhysChem ( IF 2.3 ) Pub Date : 2021-08-25 , DOI: 10.1002/cphc.202100529
Francesco Zaccaria ₁ , Stephanie C C van der Lubbe ₁ , Celine Nieuwland ₁ , Trevor A Hamlin ₁ , Célia Fonseca Guerra _{1,

2}

Affiliation

Pollution metals get intimate with G-quadruplexes! Divalent pollution metal cations bind with higher affinities to G-quadruplexes than biological occurring K⁺ and Na⁺. DFT analyses contribute to a deeper understanding of pollution metal genotoxicity by demonstrating that the enhanced affinities follow from more favorable electrostatic and donor-acceptor orbital interactions.