Diabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear factor kappa B (NF-κB) signaling pathway, a classical pathway that triggers inflammatory response, is regulated by many regulators, such as glycogen synthase kinase 3 beta (GSK-3β). Noncoding RNAs, a large class of molecules that regulate gene expression at the posttranscriptional or posttranslational level, play an important role in various stages of wound healing, especially in the stage of inflammation. Herein, we summarized the roles of noncoding RNAs in the NF-κB/GSK-3β signaling, which might provide new ideas for the treatment of diabetic wound healing.

中文翻译：

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通过非编码 RNA 相互作用和 GSK-3β/NF-κB 信号相互作用调节伤口愈合

糖尿病足溃疡严重危害着患者的身心健康。由于炎症持续时间长，糖尿病不愈合伤口的治疗是世界上最突出的医疗保健问题之一。核因子κB（NF- κ B）信号传导途径，一个经典途径触发炎症反应，是由许多调节剂，如糖原合酶调节激酶3β（GSK-3 β）。非编码 RNA 是一大类在转录后或翻译后水平调节基因表达的分子，在伤口愈合的各个阶段，尤其是在炎症阶段发挥着重要作用。在此，我们总结了非编码RNA的作用在NF- κ B / GSK-3 β 信号，这可能为糖尿病伤口愈合的治疗提供新的思路。