Over the last 60 years, phthalate plasticizer production has increased manifold, owing to their inexpensive, multipurpose, durable, and lightweight nature. These characteristics have raised the demand for phthalate plasticizers that will continue to grow over the coming years. However, with increased phthalate plasticizer production comes increased water pollution and soil pollution, as well as serious harm to human health. The recent studies mainly focused on plasticizing properties, plasticizing mechanism, and raw material sources, but the relationship of chemical structure of the plasticizer and its toxicity has never been reported. In this study, we synthesized three kinds of renewable atom-efficient dendrimer-like plasticizers based on toxic tung oil (DPTs). Plasticizing properties, plasticizing mechanism, and toxicity of DPTs were investigated. The results showed that polyvinyl chloride (PVC)/40 phr DPT has superior plasticizing properties and migration resistance than PVC/40 phr dioctyl phthalate. All DPT plasticizers have toxic doses of 5000 mg/kg and are non-toxic. These DPTs are potential to replace reproductive toxic phthalate plasticizers in food packaging materials, toys, and medical equipment.

在过去的 60 年中，邻苯二甲酸酯增塑剂的生产由于其廉价、多用途、耐用和重量轻的特性而增加了多方面。这些特性提高了对邻苯二甲酸酯增塑剂的需求，未来几年将继续增长。然而，随着邻苯二甲酸酯增塑剂产量的增加，水污染和土壤污染也随之增加，对人体健康也造成严重危害。近期的研究主要集中在增塑性能、增塑机理和原料来源等方面，但从未报道过增塑剂的化学结构与其毒性的关系。在这项研究中，我们合成了三种基于有毒桐油（DPTs）的可再生原子高效树枝状增塑剂。塑化性能、塑化机理、并研究了 DPTs 的毒性。结果表明，聚氯乙烯 (PVC)/40 phr DPT 比 PVC/40 phr 邻苯二甲酸二辛酯具有更好的增塑性能和抗迁移性。所有 DPT 增塑剂的毒性剂量为 5000 mg/kg，并且是无毒的。这些 DPT 有可能在食品包装材料、玩具和医疗设备中替代具有生殖毒性的邻苯二甲酸酯增塑剂。