Cutaneous melanoma has an aggressive clinical presentation, showing rapid rate of growth and metastatic dissemination due to the permanence of cancer stem cells. The present study was to evaluate the expression of the self-renewal regulatory factor and the clinical significance of the transcription factor OCT4 in melanoma. Melanoma tissues were stained by immunohistochemistry and the correlation between the expression of this marker was determined through clinical-pathological variables and survival outcomes. Positive expression of nuclear and cytoplasmic OCT4 was observed in 49% and 41.2% of cases, respectively. The positive expression of nuclear OCT4 in melanoma was significantly associated with prognostic factors, such as Breslow depth, Clark's level, ulceration and metastasis. Survival of patients was 56% compared to positive nuclear OCT4 expression and 94.2% when compared to the low expression of the gene. Nuclear OCT4 positive genotype indicated aggressive tumor behavior with a worse clinical outcome, which indicates OCT4 as a useful biomarker in the prognosis of melanoma.

中文翻译：

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癌症干细胞标志物 OCT4 的表达与皮肤黑色素瘤的较差预后和生存相关。


皮肤黑色素瘤具有侵袭性的临床表现，由于癌症干细胞的持久性而表现出快速的生长和转移性扩散。本研究旨在评价黑色素瘤中自我更新调节因子的表达以及转录因子OCT4的临床意义。通过免疫组织化学对黑色素瘤组织进行染色，并通过临床病理变量和生存结果确定该标记物表达之间的相关性。核和细胞质 OCT4 阳性表达率分别为 49% 和 41.2%。黑色素瘤中核OCT4的阳性表达与Breslow深度、Clark's水平、溃疡和转移等预后因素显着相关。与核 OCT4 表达阳性的患者相比，患者的生存率为 56%；与该基因低表达的患者相比，患者的生存率为 94.2%。核 OCT4 阳性基因型表明侵袭性肿瘤行为和较差的临床结果，这表明 OCT4 作为黑色素瘤预后的有用生物标志物。