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ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy
Cancer Cell ( IF 48.8 ) Pub Date : 2021-08-26 , DOI: 10.1016/j.ccell.2021.08.002
Lei Shen 1 , Youqiong Ye 2 , Hongxiang Sun 3 , Bing Su 3
Affiliation  

The precise role of intestinal ILC3s in cancer remains largely unknown. Published in Cell, Goc et al. describe ILC3 function and plasticity in tumors. ILC3s may lose their identity and thus become either ILC1s or exhausting-ILC3s, which could in turn reshape the gut microbiome for colorectal cancer progression and immunotherapy resistance.



中文翻译:

微生物组介导的肿瘤进展和免疫治疗中的 ILC3 可塑性

肠道 ILC3 在癌症中的确切作用在很大程度上仍然未知。发表于Cell、Goc 等。描述 ILC3 在肿瘤中的功能和可塑性。ILC3s 可能会失去它们的身份,从而变成 ILC1s 或耗尽的 ILC3s,这反过来可能会重塑肠道微生物群,以应对结直肠癌的进展和免疫治疗耐药性。

更新日期:2021-10-11
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