Combating the ongoing COVID-19 pandemic has put the spotlight on nutritional support of the immune system through consumption of vitamins C and D. Accordingly, there are urgent demands for an effective on-the-spot multi-vitamin self-testing platform that monitors the levels of these immune-supporting micronutrients for guiding precision nutrition recommendations. Herein, we present a compact bioelectronic dual sensor chip aimed at frequent on-the-spot simultaneous monitoring of the salivary vitamin C and D dynamics. The new bioelectronic chip combines a new electrocatalytic vitamin C amperometric assay along with competitive vitamin D immunoassay on neighboring electrodes, to perform selective and cross-talk free detection of both vitamins in a 10-μL saliva sample within 25min. The distinct vitamin C or D temporal profiles obtained for different individuals after vitamin supplementation indicate the potential of the new bioelectronic chip strategy for enhancing personalized nutrition towards guiding dietary interventions to meet individual nutrition needs and promote immune system health.

抗击当前的 COVID-19 大流行，通过摄入维生素 C 和 D 来支持免疫系统的营养支持成为人们关注的焦点。因此，迫切需要一个有效的现场多种维生素自测平台来监测这些支持免疫的微量营养素的水平可用于指导精准营养建议。在此，我们提出了一种紧凑型生物电子双传感器芯片，旨在频繁现场同时监测唾液维生素 C 和 D 动态。新型生物电子芯片将新型电催化维生素 C 电流分析法与相邻电极上的竞争性维生素 D 免疫分析相结合，可在 25 分钟内对 10 µL 唾液样本中的两种维生素进行选择性且无串扰的检测。补充维生素后，不同个体获得的不同维生素 C 或 D 时间分布表明，新的生物电子芯片策略在增强个性化营养、指导饮食干预以满足个人营养需求和促进免疫系统健康方面具有潜力。