Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies,Atherosclerosis

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Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies
Atherosclerosis ( IF 4.9 ) Pub Date : 2021-08-26 , DOI: 10.1016/j.atherosclerosis.2021.08.037
Naoki Nakaya ₁ , Tian Xie ₂ , Bart Scheerder ₃ , Naho Tsuchiya ₄ , Akira Narita ₅ , Tomohiro Nakamura ₄ , Hirohito Metoki ₆ , Taku Obara ₇ , Mami Ishikuro ₄ , Atsushi Hozawa ₄ , Harold Snieder ₂ , Shinichi Kuriyama ₈

Affiliation

Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Health Science, Saitama Prefectural University, Japan.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Center for Development & Innovation, University Medical Center Groningen, Groningen, the Netherlands.
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Tohoku University Graduate School of Medicine, Sendai, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Division of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.

Background and aims

Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations.

Methods

This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006–2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013–2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age.

Results

The husbands' and wives’ average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36–1.55) vs. 1.20 (1.05–1.38) for hypertension to 6.86 (6.30–7.48) vs. 4.60 (3.52–6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20–39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts.

Conclusions

Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.

中文翻译：

配偶心脏代谢危险因素的相似性：来自两项大型生物样本库研究的荷兰和日本数据的横断面比较

背景和目标

很少有研究检查和比较不同人群中的配偶一致性。本研究旨在量化和比较荷兰和日本人群在心脏代谢危险因素和疾病方面的配偶相似性。

方法

这项横断面研究包括 28,265 对荷兰生命线队列研究配偶对（2006-2013 年）和 5,391 对日本东北医疗大银行组织（ToMMo）队列研究对（2013-2016 年）。使用根据配偶年龄调整的 Pearson 相关或逻辑回归分析来评估配偶在心脏代谢危险因素方面的相似性。

结果

Lifelines 和 ToMMo 队列中丈夫和妻子的平均年龄分别为 50.0 和 47.7 岁以及 63.2 和 60.4 岁。在两个队列中，所有心脏代谢危险因素和感兴趣的疾病都发生了显着的配偶相似性。年龄调整相关系数的范围从 0.032 到 0.263，在人体测量特征中观察到的相关性最强。Lifelines与ToMMo 队列的配偶优势比 [95% 置信区间]范围从高血压的1.45 (1.36-1.55)与1.20 (1.05-1.38) 到 6.86 (6.30-7.48)与目前吸烟为 4.60 (3.52–6.02)。在两个队列中观察到足够的体力活动的配偶一致性随着年龄增加的趋势。对于目前的吸烟情况，20-39 岁的人在两个队列中表现出最强的一致性。与日本同行相比，荷兰人在人体测量特征和生活习惯（吸烟和饮酒）方面表现出更强的相似性。