Despite the routine use of antenatal steroids, exogenous surfactants, and different noninvasive ventilation methods, many extremely low gestational age neonates, preterm, and term infants eventually require invasive ventilation. In addition to prematurity, mechanical ventilation itself can induce ventilator-induced lung injury leading to lifelong pulmonary sequelae. Besides conventional mechanical ventilation, high-frequency oscillatory ventilation (HFOV) with tidal volumes below dead space and high ventilation frequencies is used either as a primary or rescue therapy in severe neonatal respiratory failure.

中文翻译：

---

早产儿高频通气期间呼吸机设置的计算机模拟数值模拟

尽管常规使用产前类固醇、外源性表面活性剂和不同的无创通气方法，但许多极低胎龄新生儿、早产儿和足月婴儿最终需要有创通气。除了早产，机械通气本身也会引起呼吸机引起的肺损伤，从而导致终身肺后遗症。除了常规机械通气外，潮气量低于死腔和高通气频率的高频振荡通气 (HFOV) 被用作严重新生儿呼吸衰竭的主要或抢救疗法。