Structure-guided identification of a peptide for bio-enabled gold nanoparticle synthesis,Biotechnology and Bioengineering

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Structure-guided identification of a peptide for bio-enabled gold nanoparticle synthesis
Biotechnology and Bioengineering ( IF 3.5 ) Pub Date : 2021-08-26 , DOI: 10.1002/bit.27927
Amar Thaker _{1,

2} , Luqmanal Sirajudeen _{1,

2} , Chad R Simmons ₃ , Brent L Nannenga _{1,

2}

Affiliation

In this study, we show that maltose-binding protein (MBP) is capable of facilitating stable gold nanoparticle synthesis, and a structure of MBP in the presence of gold ions was determined by X-ray crystallography. Using this high-resolution structure of gold ion bound MBP, a peptide (AT1) was selected and synthesized and was shown to also aid in the synthesis of stable gold nanoparticles under similar experimental conditions to those used for protein facilitated synthesis. This structure-based approach represents a new potential method for the selection of peptides capable of facilitating stable nanoparticle synthesis.

中文翻译：

用于生物金纳米粒子合成的肽的结构引导鉴定

在这项研究中，我们表明麦芽糖结合蛋白 (MBP) 能够促进稳定的金纳米颗粒合成，并且通过 X 射线晶体学确定了金离子存在下 MBP 的结构。使用这种与金离子结合的 MBP 的高分辨率结构，选择并合成了一种肽 (AT1)，并且表明它还有助于在与用于蛋白质促进合成的实验条件相似的实验条件下合成稳定的金纳米颗粒。这种基于结构的方法代表了一种新的潜在方法，用于选择能够促进稳定纳米颗粒合成的肽。

更新日期：2021-08-26

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