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Apoptosis induction by the stem cell factor LIN28A
Biology of the Cell ( IF 2.4 ) Pub Date : 2021-08-26 , DOI: 10.1111/boc.202100011
Yael Attali-Padael 1 , Leah Armon 1 , Achia Urbach 1
Affiliation  

Lin28A and its paralog Lin28B are RNA binding proteins expressed in stem and progenitor cells, regulating the balance between their proliferation and differentiation. In-vivo and in-vitro experiments have shown that overexpression of these genes leads to abnormal cell proliferation, which results in many cases in cell transformation and tumor formation.

中文翻译:

干细胞因子LIN28A诱导细胞凋亡

Lin28A 及其旁系同源物 Lin28B 是在干细胞和祖细胞中表达的 RNA 结合蛋白,调节它们的增殖和分化之间的平衡。体内体外实验表明,这些基因的过表达会导致细胞增殖异常,这在许多情况下会导致细胞转化和肿瘤形成。
更新日期:2021-11-03
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