Introduction: Early-onset dementia (EOD), defined as dementia onset before the age of 65 years, is relatively rare, but its social impacts are significant. This study aimed to characterize the diagnosis and clinical and social status of EOD subjects in the 11 dementia centers in Chiba Prefecture, Japan. Methods: A retrospective 1-year survey was conducted. Collected data included clinical diagnosis, age at onset, age at survey, neuropsychological test, family history, employment, and living status. Results: We identified 208 EOD subjects, including 123 (59.4%), 24 (11.6%), 21 (10.1%), 17 (8.2%), and 10 (4.8%) with Alzheimer’s disease (AD), vascular dementia, frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies/Parkinson’s disease dementia, and alcohol-related dementia, respectively. The Mini-Mental State Examination (MMSE) score #x3c;24 was observed in 50–75% of patients and was not correlated with disease duration. Twenty-four (16.4%) subjects had positive family history of EOD. EOD subjects were at risk of early retirement, and 133 subjects lived with their family, in whom 64 (30.8%) lived with their child. Conclusion: In dementia centers, AD, FTLD, and Lewy body dementia had relatively large proportion. Employment, economy, and social supports are urgently needed for EOD subjects and their family.
Dement Geriatr Cogn Disord

中文翻译：

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日本千叶县早发性痴呆的特征：多中心调查

简介：早发性痴呆（EOD），​​定义为在 65 岁之前发病的痴呆症，相对少见，但其社会影响显着。本研究旨在描述日本千叶县 11 个痴呆症中心的 EOD 受试者的诊断、临床和社会状况。方法：进行了一项为期 1 年的回顾性调查。收集的数据包括临床诊断、发病年龄、调查年龄、神经心理测试、家族史、就业和生活状况。结果：我们确定了 208 名 EOD 受试者，包括 123 (59.4%)、24 (11.6%)、21 (10.1%)、17 (8.2%) 和 10 (4.8%) 名患有阿尔茨海默病 (AD)、血管性痴呆、额颞叶变性(FTLD)、路易体痴呆/帕金森病痴呆和酒精相关性痴呆。在 50-75% 的患者中观察到简易精神状态检查 (MMSE) 评分 #x3c;24，并且与疾病持续时间无关。24 名 (16.4%) 受试者有 EOD 阳性家族史。EOD 受试者有提前退休的风险，133 名受试者与家人同住，其中 64 名（30.8%）与子女同住。结论：在痴呆中心，AD、FTLD和路易体痴呆所占比例较大。排爆对象及其家庭迫切需要就业、经济和社会支持。
老年痴呆症认知障碍