This study summarized the benefits of oxytocin in the attenuation of coronavirus disease (COVID-19) pathogenesis. The recent outbreak of COVID-19 has become a pandemic with 7,323,761 infected patients and has created a health emergency worldwide. On the basis of the clinical study, COVID-19 shows homology with other coronavirus pathogenesis, i.e., inflammation, oxidative stress, and hyperactivation of the immune system, resulting in cytokine storm and causing acute lung infection (ALI), acute respiratory distress syndrome (ARDS), and kidney dysfunction. Oxytocin is a peptide of nine amino acids and a well-known anti-inflammatory, anti-oxidant, and immune-modulator, which is protective against ALI/ARDS, nephrotoxicity, sepsis, and ischemia- reperfusion medical condition. Oxytocin is a neuromodulator, effective for stress, anxiety, social behavior, and depression, which may be helpful for better outcomes in patients with COVID-19. Significant data show that oxytocin can be useful in the treatment of COVID-19 pathogenesis. A direct application of OT in COVID-19 is unclear; however, its use in an experimental model and humans has continuously demonstrated its safety, and its use in patients with COVID-19 is predicted to be highly beneficial.

本研究总结了催产素在减弱冠状病毒病 (COVID-19) 发病机制中的益处。最近爆​​发的 COVID-19 已成为大流行病，感染了 7,323,761 名患者，并在全球范围内造成了卫生紧急情况。根据临床研究，COVID-19与其他冠状病毒的发病机制具有同源性，即炎症、氧化应激和免疫系统过度激活，导致细胞因子风暴并引起急性肺感染（ALI）、急性呼吸窘迫综合征。 ARDS）和肾功能不全。催产素是一种由九个氨基酸组成的肽，是一种众所周知的抗炎、抗氧化和免疫调节剂，可预防 ALI/ARDS、肾毒性、败血症和缺血-再灌注医疗状况。催产素是一种神经调节剂，对压力、焦虑、社交行为、和抑郁症，这可能有助于改善 COVID-19 患者的预后。重要数据表明，催产素可用于治疗 COVID-19 发病机制。OT 在 COVID-19 中的直接应用尚不清楚；然而，它在实验模型和人类中的使用不断证明其安全性，预计它在 COVID-19 患者中的使用是非常有益的。