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Exploitation of Some Natural Products for the Prevention and/or Nutritional Treatment of SARS-CoV2 Infection
Endocrine, Metabolic & Immune Disorders - Drug Targets ( IF 2.0 ) Pub Date : 2021-06-30 , DOI: 10.2174/1871530320999200831231029
Annalisa Rizzo 1 , Raffaele Luigi Sciorsci 1 , Thea Magrone 2 , Emilio Jirillo 2
Affiliation  

Dietary habits strongly influence our health status, mostly in terms of maintenance of the inflammatory/anti-inflammatory homeostasis. High fat and high sugar diets account for the development of a low-grade inflammation, which is the pathogenic common denominator of various chronic diseases. Severe Acute Respiratory Syndrome Coronavirus (SARS)-CoV2 (COVID-19) infection affects all ages and especially frail elderly people and a nutritional intervention seems to be crucial in the course of this pandemic. The present review describes the properties of some vegetal products and their derivatives, such as Lupin sp., garlic, salvia and extra virgin olive oil (EVOO) that can be exploited for their beneficial effects, as preventive and/or nutritional treatment of coronavirus disease SARS-CoV2. Lupin, salvia, garlic and EVOO share overlapping properties, such as anti-oxidant, anti-inflammatory and anti-viral activities. Quite importantly, these products and their derivatives are able to recover the expression of angiotensin converting enzyme expression 2 on cell membrane, otherwise suppressed by COVID-19 binding and entry into cytoplasm. Dietary administration of the above nutraceuticals or their extracts may play a preventive or nutritional role in the course of SARS-CoV2 infection, even including the effects of the lockdown and the condition of inflamm-ageing.



中文翻译:

利用一些天然产物预防和/或营养治疗 SARS-CoV2 感染

饮食习惯强烈影响我们的健康状况,主要是在维持炎症/抗炎稳态方面。高脂肪和高糖饮食导致低度炎症的发展,这是各种慢性疾病的致病共同点。严重急性呼吸系统综合症冠状病毒 (SARS)-CoV2 (COVID-19) 感染影响所有年龄段的人,尤其是体弱的老年人,在这种大流行过程中,营养干预似乎至关重要。本综述描述了一些植物产品及其衍生物的特性,例如羽扇豆、大蒜、鼠尾草和特级初榨橄榄油 (EVOO),可利用其有益作用,作为冠状病毒疾病的预防和/或营养治疗SARS-CoV-2。羽扇豆、丹参、大蒜和 EVOO 具有重叠的特性,如抗氧化、抗炎和抗病毒活性。非常重要的是,这些产品及其衍生物能够恢复细胞膜上血管紧张素转化酶表达 2 的表达,否则会被 COVID-19 结合和进入细胞质所抑制。上述营养食品或其提取物的膳食管理可能在 SARS-CoV2 感染过程中起到预防或营养作用,甚至包括封锁的影响和炎症老化的情况。

更新日期:2021-08-26
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