Hyperhomocysteinemia (HHcy) has been considered a risk factor for different diseases, including cardiovascular disease (CVD), inflammation, neurological diseases, cancer, and many other pathological conditions. Likewise, arachidonic acid (AA) metabolism is implicated in both vascular homeostasis and inflammation, as shown by the development of CVD, following the imbalance of its metabolites. This review summarizes how homocysteine (Hcy) can influence the metabolism of AA. In silico literature searches were performed on PubMed and Scopus as main sources. Several studies have shown that altered levels of Hcy, through AA release and metabolism, can influence the synthesis and the activity of prostaglandins (PGs), prostacyclin (PGI2), thromboxane (TXA), epoxyeicosatrienoic acids (EETs), and hydroxyeicosatetraenoic acids (HETEs). It is believed that by targeting Hcy in the AA pathways, novel compounds with better pharmacological and pharmacodynamics benefits may be obtained and that this information is valuable for a dietician to manipulate diets to improve health.

高同型半胱氨酸血症 (HHcy) 已被认为是不同疾病的危险因素，包括心血管疾病 (CVD)、炎症、神经系统疾病、癌症和许多其他病理状况。同样，花生四烯酸 (AA) 代谢与血管稳态和炎症有关，正如其代谢物失衡后 CVD 的发展所示。本综述总结了同型半胱氨酸 (Hcy) 如何影响 AA 的代谢。以 PubMed 和 Scopus 为主要来源进行了计算机模拟文献检索。多项研究表明，通过 AA 释放和代谢，改变 Hcy 水平会影响前列腺素 (PG)、前列环素 (PGI2)、血栓烷 (TXA)、环氧二十碳三烯酸 (EET) 和羟基二十碳四烯酸 (HETE) 的合成和活性）。