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False Positive of 68Ga-DOTATATE PET-CT in a Paraganglioma
Endocrine, Metabolic & Immune Disorders - Drug Targets ( IF 2.0 ) Pub Date : 2021-06-30 , DOI: 10.2174/1871530320666200821141256
Benedetta Zampetti 1 , Roberto Attanasio 2 , Marco Boniardi 3 , Renato Cozzi 1
Affiliation  

Background: Functional imaging with 68Ga-DOTATATE PET-CT is widely employed to detect both primary and metastatic pheochromocytomas and paragangliomas (PGL), but its results may be occasionally misleading as in the case here reported.

Case Presentation: We report here a 75-year-old woman with an interaortocaval PGL that was diagnosed after a hypertensive crisis occurring during the resection of a kidney tumor. 68Ga-DOTATATE PET-CT disclosed pathologic uptake in the abdomen and at the iliac crest. After the resection of the abdominal tumor, with the histological confirmation of PGL, arterial blood pressure and metanephrine levels were normalized. Genetic testing was negative. Thereafter, the bone lesion increased in size and became painful, requiring multiple medications. A selective biopsy disclosed a metastatic lesion arising from the renal tumor.

Conclusion: The false-positive result of 68Ga-DOTATATE PET-CT is discussed.



中文翻译:

副神经节瘤中 68Ga-DOTATATE PET-CT 的假阳性

背景:68 Ga-DOTATATE PET-CT 的功能成像被广泛用于检测原发性和转移性嗜铬细胞瘤和副神经节瘤 (PGL),但其结果有时可能会产生误导,如本文报道的病例。

病例介绍:我们在此报告一名 75 岁女性,在切除肾脏肿瘤期间发生高血压危象后被诊断出患有主动脉腔间 PGL。68 Ga-DOTATATE PET-CT 显示腹部和髂嵴的病理摄取。腹部肿瘤切除后,经 PGL 组织学证实,动脉血压和变肾上腺素水平恢复正常。基因检测呈阴性。此后,骨病灶变大并变得疼痛,需要多种药物治疗。选择性活检显示肾肿瘤引起的转移性病变。

结论:讨论了68 Ga-DOTATATE PET-CT的假阳性结果。

更新日期:2021-08-26
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