The gout-induced continuous deposition of urate in the kidney tissues is the main cause of renal injury, for which cystatin C (Cys C) is an important indicator. This research analyzed the correlation between general renal injury indicators and serum Cys C level, and further investigated the potential of Cys C in renal injury diagnosis. A total of 140 gout patients with renal injury (GRI) were recruited and grouped by their glomerular filtration rate (GFR). Urea nitrogen, uric acid, creatinine, and Cys C levels in the serum were evaluated. The diagnostic efficacy of serum Cys C was evaluated by the nonparametric receiver operating characteristic analysis. Serum Cys C level was increased with decreased GFR in GRI. Urea nitrogen, uric acid, and creatinine levels in the serum showed positive correlations with Cys C level. The area under the curve for serum Cys C was 0.8589 (P < 0.001). In conclusion, this research demonstrated that the serum Cys C level was a precise diagnostic marker for GFR and renal damage evaluation, and showed a significant diagnostic value for renal injury in patients with gout.

中文翻译：

---

肾损伤痛风患者血清胱抑素C与肾功能的相关性

痛风引起的肾组织尿酸盐持续沉积是肾损伤的主要原因，其中胱抑素C（Cys C）是重要指标。本研究分析了一般肾损伤指标与血清Cys C水平的相关性，进一步探讨了Cys C在肾损伤诊断中的潜力。共招募了 140 名患有肾损伤 (GRI) 的痛风患者，并根据他们的肾小球滤过率 (GFR) 进行分组。评估血清中的尿素氮、尿酸、肌酐和半胱氨酸 C 水平。通过非参数接受者操作特征分析评估血清Cys C的诊断效力。血清 Cys C 水平随着 GRI 中 GFR 的降低而增加。血清中尿素氮、尿酸和肌酐水平与Cys C水平呈正相关。P  < 0.001)。综上所述，本研究表明，血清Cys C水平是GFR和肾损伤评估的精准诊断标志物，对痛风患者的肾损伤表现出显着的诊断价值。