PURPOSE Poor sleep accompanied by elevated TSH (thyroid stimulating hormone) levels is not uncommon since TSH secretion is controlled by the circadian rhythm. However, the relationship between poor sleep and TSH elevation is unclear; hence, we aimed to elucidate this relationship by conducting a cross-sectional and longitudinal study. METHODS Participants with isolated elevated (N = 168) and normal (N = 119) TSH concentrations were recruited, and the Pittsburgh Sleep Quality Index (PSQI) was used to assess the sleep status. Subjects with an isolated TSH elevation were followed up longitudinally. The serum TSH concentration was remeasured after sleep status improved. RESULTS The proportions of poor sleep and occasional poor sleep in subjects with isolated TSH elevation were significantly higher than those with normal TSH levels (70.24% vs. 49.58%, p = 0.001; 9.52% vs. 1.68%, p = 0.006). Subjects with isolated TSH elevation had significantly higher PSQI scores in the subjective sleep quality, sleep latency, sleep duration, and habitual sleep efficiency dimensions than those with normal TSH levels (all p < 0.05). Poor sleep was significantly associated with isolated TSH elevation in the multiple logistic regression analysis [odds ratio (OR) = 2.396, p = 0.001]. Among subjects with an isolated TSH elevation at baseline, the percentage of TSH normalization was significantly higher in those who slept better than in those who still slept poorly (85.42% vs. 6.45%, p < 0.001). CONCLUSIONS This study revealed that isolated elevated TSH concentrations normalize when the sleep status is improved; hence, we recommend that clinicians thoroughly assess the sleep status of patients and remeasure TSH concentrations after sleep status improves.

中文翻译：

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促甲状腺激素水平升高与睡眠不足有关：一项横断面和纵向研究。

目的 伴随TSH（促甲状腺激素）水​​平升高的睡眠不佳并不少见，因为TSH的分泌受昼夜节律控制。然而，睡眠不佳与 TSH 升高之间的关系尚不清楚；因此，我们旨在通过进行横断面和纵向研究来阐明这种关系。方法招募TSH浓度升高（N = 168）和正常（N = 119）的参与者，并使用匹兹堡睡眠质量指数（PSQI）评估睡眠状态。对孤立性 TSH 升高的受试者进行纵向随访。睡眠状态改善后重新测量血清TSH浓度。结果 孤立性 TSH 升高的受试者睡眠不良和偶发性睡眠不良的比例显着高于 TSH 水平正常者（70.24% vs. 49.58%，p = 0.001；9.52% 与 1.68%，p = 0.006）。孤立性 TSH 升高的受试者在主观睡眠质量、睡眠潜伏期、睡眠时长和习惯性睡眠效率维度的 PSQI 评分显着高于 TSH 水平正常的受试者（均 p < 0.05）。在多元逻辑回归分析中，睡眠不足与孤立的 TSH 升高显着相关 [优势比 (OR) = 2.396，p = 0.001]。在基线时 TSH 单独升高的受试者中，睡眠良好的受试者的 TSH 正常化百分比显着高于睡眠不佳的受试者（85.42% 对 6.45%，p < 0.001）。结论 本研究表明，当睡眠状态改善时，孤立的 TSH 浓度升高会正常化。因此，