Acinetobacter variabilis (formerly genospecies 15 sensu Tjernberg and Ursing) has been isolated from humans and animals and was proposed to be a novel species in 2015. A multidrug-resistant A. variabilis isolate, RYU24, was obtained in 2012 from an inpatient in Okinawa, Japan, with no record of overseas travel. The isolate was resistant to carbapenems, aminoglycosides and ciprofloxacin, with minimum inhibitory concentrations (MICs) of 32 µg ml−1 for imipenem and meropenem; > 1024 µg ml−1 for amikacin, arbekacin, gentamicin and tobramycin; and 8 µg ml−1 for ciprofloxacin. The isolate was found to harbour a 68-kbp plasmid carrying bla NDM-1, which encodes New Delhi metallo-β-lactamase-1 (NDM-1); bla OXA-420, which encodes an OXA-58-like carbapenemase and; armA, which encodes ArmA 16S rRNA methylase conferring pan-aminoglycoside resistance. To our knowledge, this is the first report of a plasmid harbouring the three major drug-resistance genes, bla NDM-1, bla OXA-420 and armA.

中文翻译：

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日本变异不动杆菌临床分离株中编码blaNDM-1、blaOXA-420和armA的多重耐药质粒的出现

变异不动杆菌 （原基因种 15 sensu Tjernberg 和 Ursing）已从人类和动物中分离出来，并于 2015 年被提议为新物种。2012 年从冲绳的一名住院患者身上获得了一种多药耐药变异 A. variabilis分离株 RYU24，日本，没有海外旅行记录。该分离株对碳青霉烯类、氨基糖苷类和环丙沙星耐药，亚胺培南和美罗培南的最低抑菌浓度 (MIC) 为 32 µg ml -1；> 1024 µg ml -1对于阿米卡星、阿贝卡星、庆大霉素和妥布霉素；和 8 µg ml -1用于环丙沙星。发现该分离物含有携带bla NDM-1的 68-kbp 质粒 ，编码新德里金属-β-内酰胺酶-1（NDM-1）；bla OXA-420，编码 OXA-58 样碳青霉烯酶和；armA，其编码赋予泛氨基糖苷抗性的 ArmA 16S rRNA 甲基化酶。据我们所知，这是含有三个主要耐药基因bla NDM-1、bla OXA-420和armA的质粒的第一份报告。