Thoracic endovascular aortic repair (TEVAR) has been accepted as the mainstream treatment for type B aortic dissection, but post-TEVAR biomechanical-related complications are still a major drawback. Unfortunately, the stent-graft (SG) configuration after implantation and biomechanical interactions between the SG and local aorta are usually unknown prior to a TEVAR procedure. The ability to obtain such information via personalised computational simulation would greatly assist clinicians in pre-surgical planning. In this study, a virtual SG deployment simulation framework was developed for the treatment for a complicated aortic dissection case. It incorporates patient-specific anatomical information based on pre-TEVAR CT angiographic images, details of the SG design and the mechanical properties of the stent wire, graft and dissected aorta. Hyperelastic material parameters for the aortic wall were determined based on uniaxial tensile testing performed on aortic tissue samples taken from type B aortic dissection patients. Pre-stress conditions of the aortic wall and the action of blood pressure were also accounted for. The simulated post-TEVAR configuration was compared with follow-up CT scans, demonstrating good agreement with mean deviations of 5.8% in local open area and 4.6 mm in stent strut position. Deployment of the SG increased the maximum principal stress by 24.30 kPa in the narrowed true lumen but reduced the stress by 31.38 kPa in the entry tear region where there was an aneurysmal expansion. Comparisons of simulation results with different levels of model complexity suggested that pre-stress of the aortic wall and blood pressure inside the SG should be included in order to accurately predict the deformation of the deployed SG.

胸腔内主动脉修复术（TEVAR）已被公认为 B 型主动脉夹层的主流治疗方法，但 TEVAR 术后生物力学相关并发症仍然是主要缺点。不幸的是，在 TEVAR 手术之前，植入后的覆膜支架 (SG) 配置以及 SG 和局部主动脉之间的生物力学相互作用通常是未知的。通过个性化计算模拟获得此类信息的能力将极大地帮助临床医生进行术前计划。在这项研究中，开发了一个虚拟 SG 部署模拟框架，用于治疗复杂的主动脉夹层病例。它结合了基于 TEVAR 前 CT 血管造影图像的患者特定解剖信息、SG 设计的细节以及支架线、移植物和解剖主动脉的机械特性。主动脉壁的超弹性材料参数是基于对取自 B 型主动脉夹层患者的主动脉组织样本进行的单轴拉伸试验确定的。还考虑了主动脉壁的预应力条件和血压的作用。将模拟的 TEVAR 后配置与后续 CT 扫描进行比较，表明局部开放区域的平均偏差为 5.8%，支架支柱位置的平均偏差为 4.6 mm。SG 的部署使变窄的真管腔中的最大主应力增加了 24.30 kPa，但在动脉瘤扩张的入口撕裂区域中的应力降低了 31.38 kPa。