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Methods and Developments in Graphical Pangenomics
Journal of the Indian Institute of Science ( IF 2.3 ) Pub Date : 2021-08-24 , DOI: 10.1007/s41745-021-00255-z
Joseph Outten 1 , Andrew Warren 1
Affiliation  

Pangenomes are organized collections of the genomic information from related individuals or groups. Graphical pangenomics is the study of these pangenomes using graphical methods to identify and analyze genes, regions, and mutations of interest to an array of biological questions. This field has seen significant progress in recent years including the development of graph based models that better resolve biological phenomena, and an explosion of new tools for mapping reads, creating graphical genomes, and performing pangenome analysis. In this review, we discuss recent developments in models, algorithms associated with graphical genomes, and comparisons between similar tools. In addition we briefly discuss what these developments may mean for the future of genomics.



中文翻译:

图形泛基因组学的方法和发展

泛基因组是来自相关个人或群体的基因组信息的有组织集合。图解泛基因组学是对这些泛基因组的研究,使用图解方法来识别和分析一系列生物学问题的感兴趣的基因、区域和突变。近年来,该领域取得了重大进展,包括开发更好地解决生物现象的基于图的模型,以及用于映射读取、创建图形基因组和执行泛基因组分析的新工具的爆炸式增长。在这篇综述中,我们讨论了模型的最新发展、与图形基因组相关的算法以及类似工具之间的比较。此外,我们简要讨论了这些发展对基因组学的未来可能意味着什么。

更新日期:2021-08-25
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