This work was aiming to design novel bio-composite (BC) materials based on microwave-prepared AuNPs-loaded Zeolite-A (ZA-Au) and nano-hydroxyapatite (HA). Ciprofloxacin drug was uploaded onto the BC entities to provide a potential treatment for osteomyelitis. The prepared BCs containing the lowest and highest (10 and 40%) active weight ratios of ZA-Au were prepared and coded as ZA-Au-10 and ZA-Au-40, respectively. The XRD, FTIR, TEM, and SEM supported with EDX technique were used for samples characterization. Both bio-mixtures were able to induce hydroxyapatite layer after immersion into SBF for 15 days. Cytotoxic evaluation of all prepared materials indicated their safe and nontoxic nature. Both BCs showed significant improvement in their drug release profiles and rates, compared to either parent constituents (HA or ZA-Au). The total cumulative amounts of released antibiotic from ZA-Au-10 and ZA-Au-40 were 1.324 ± 0.21 and 1.218 ± 0.13 mg, respectively. The application of the Higuchi square root model on the drug release profiles for both BCs specified the diffusion-controlled manner for the drug elution. This novel BC will combine the high bioactivity of the nano-HA with the given strength and defined porosity of the zeolite structure, to help effectively in delivering the drug in a regular and prolonged manner. Overall, the formed novel bio-composites are cost-effective and proved to be highly efficient as a controlled drug delivery system for ciprofloxacin.

这项工作旨在设计基于微波制备的负载 AuNPs 的沸石-A (ZA-Au) 和纳米羟基磷灰石 (HA) 的新型生物复合 (BC) 材料。环丙沙星药物被上传到 BC 实体，为骨髓炎提供潜在的治疗方法。制备含有最低和最高（10% 和 40%）ZA-Au 活性重量比的制备的 BC，并分别编码为 ZA-Au-10 和 ZA-Au-40。使用 EDX 技术支持的 XRD、FTIR、TEM 和 SEM 用于样品表征。在浸入 SBF 15 天后，两种生物混合物都能够诱导羟基磷灰石层。所有制备材料的细胞毒性评估表明其安全无毒。与母体成分（HA 或 ZA-Au）相比，两种 BC 的药物释放曲线和速率都有显着改善。ZA-Au-10 和 ZA-Au-40 释放的抗生素的总累积量分别为 1.324 ± 0.21 和 1.218 ± 0.13 mg。Higuchi 平方根模型在两种 BC 的药物释放曲线上的应用指定了药物洗脱的扩散控制方式。这种新型 BC 将纳米 HA 的高生物活性与沸石结构的给定强度和确定的孔隙率相结合，有助于以规则和长时间的方式有效地输送药物。总体而言，形成的新型生物复合材料具有成本效益，并且被证明作为环丙沙星的受控给药系统是高效的。Higuchi 平方根模型在两种 BC 的药物释放曲线上的应用指定了药物洗脱的扩散控制方式。这种新型 BC 将纳米 HA 的高生物活性与沸石结构的给定强度和确定的孔隙率相结合，有助于以规则和长时间的方式有效地输送药物。总体而言，形成的新型生物复合材料具有成本效益，并且被证明作为环丙沙星的受控给药系统是高效的。Higuchi 平方根模型在两种 BC 的药物释放曲线上的应用指定了药物洗脱的扩散控制方式。这种新型 BC 将纳米 HA 的高生物活性与沸石结构的给定强度和确定的孔隙率相结合，有助于以规则和长时间的方式有效地输送药物。总体而言，形成的新型生物复合材料具有成本效益，并且被证明作为环丙沙星的受控给药系统是高效的。