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The multidimensional role of the Wnt/β-catenin signaling pathway in human malignancies
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-08-25 , DOI: 10.1002/jcp.30561 Ishita S Hiremath 1 , Arul Goel 2 , Sudha Warrier 3, 4 , Alan Prem Kumar 5, 6, 7 , Gautam Sethi 5, 7 , Manoj Garg 8
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-08-25 , DOI: 10.1002/jcp.30561 Ishita S Hiremath 1 , Arul Goel 2 , Sudha Warrier 3, 4 , Alan Prem Kumar 5, 6, 7 , Gautam Sethi 5, 7 , Manoj Garg 8
Affiliation
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Several signaling pathways have been identified as important for developmental processes. One of such important cascades is the Wnt/β-catenin signaling pathway, which can regulate various physiological processes such as embryonic development, tissue homeostasis, and tissue regeneration; while its dysregulation is implicated in several pathological conditions especially cancers. Interestingly, deregulation of the Wnt/β-catenin pathway has been reported to be closely associated with initiation, progression, metastasis, maintenance of cancer stem cells, and drug resistance in human malignancies. Moreover, several genetic and experimental models support the inhibition of the Wnt/β-catenin pathway to answer the key issues related to cancer development. The present review focuses on different regulators of Wnt pathway and how distinct mutations, deletion, and amplification in these regulators could possibly play an essential role in the development of several cancers such as colorectal, melanoma, breast, lung, and leukemia. Additionally, we also provide insights on diverse classes of inhibitors of the Wnt/β-catenin pathway, which are currently in preclinical and clinical trial against different cancers.
中文翻译：
Wnt/β-catenin 信号通路在人类恶性肿瘤中的多维作用
几种信号通路已被确定为对发育过程很重要。Wnt/β-catenin信号通路就是其中一个重要的级联通路，它可以调节胚胎发育、组织稳态和组织再生等各种生理过程；而它的失调与几种病理状况有关，尤其是癌症。有趣的是，据报道，Wnt/β-catenin 通路的失调与癌症干细胞的起始、进展、转移、维持和人类恶性肿瘤的耐药性密切相关。此外，一些遗传和实验模型支持抑制 Wnt/β-catenin 途径，以解决与癌症发展相关的关键问题。本综述侧重于 Wnt 通路的不同调节因子以及不同的突变如何，这些调节因子的缺失和扩增可能在结直肠癌、黑色素瘤、乳腺癌、肺癌和白血病等几种癌症的发展中发挥重要作用。此外，我们还提供了关于 Wnt/β-catenin 通路的不同类型抑制剂的见解，这些抑制剂目前正处于针对不同癌症的临床前和临床试验中。
更新日期：2021-08-25
中文翻译：
Wnt/β-catenin 信号通路在人类恶性肿瘤中的多维作用
几种信号通路已被确定为对发育过程很重要。Wnt/β-catenin信号通路就是其中一个重要的级联通路，它可以调节胚胎发育、组织稳态和组织再生等各种生理过程；而它的失调与几种病理状况有关，尤其是癌症。有趣的是，据报道，Wnt/β-catenin 通路的失调与癌症干细胞的起始、进展、转移、维持和人类恶性肿瘤的耐药性密切相关。此外，一些遗传和实验模型支持抑制 Wnt/β-catenin 途径，以解决与癌症发展相关的关键问题。本综述侧重于 Wnt 通路的不同调节因子以及不同的突变如何，这些调节因子的缺失和扩增可能在结直肠癌、黑色素瘤、乳腺癌、肺癌和白血病等几种癌症的发展中发挥重要作用。此外，我们还提供了关于 Wnt/β-catenin 通路的不同类型抑制剂的见解，这些抑制剂目前正处于针对不同癌症的临床前和临床试验中。
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