Purpose: This review describes the current scientific evidence of therapeutic options in unresectable oral squamous cell carcinoma.
Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched MEDLINE (Via PubMed) to identify studies assessing treatments for unresectable oral squamous cell carcinoma. The methodological quality assessment of the included studies was performed using the Joanna Briggs Institute (JBI) checklist tool. The evidence was organized and presented using tables and narrative synthesis.
Results: Thirty-three studies met the eligibility criteria. Most studies had an observational design. The sample size varied from 16 to 916 participants. The methodology quality of the included studies ranged from 2.5 to 10 using the JBI tool. Overall, the optimal treatment of patients with unresectable oral cancer is challenging, so there is a sprinkling of studies assessing a variety of therapeutic options, such as radiotherapy, chemotherapy, concurrent chemoradiotherapy, immunotherapy, targeted therapy plus chemotherapy or radiotherapy, and gene therapy plus chemotherapy.
Conclusion: There is lacking evidence about the benefits of some therapeutic options for unresectable oral squamous cell carcinoma. Overall, these patients can be treated using a multimodal approach such as concurrent chemoradiotherapy or induction chemotherapy followed by chemoradiotherapy, which have shown good clinical outcomes. However, other options could be considered depending on the assessment of risk/benefits, tumor extension, and patient values and preferences.

Keywords: mouth neoplasms, unresectable oral cancer, oral squamous cell carcinoma, treatment, therapy


中文翻译：

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不可切除口腔鳞状细胞癌的治疗选择：系统评价

目的：本综述描述了目前不可切除的口腔鳞状细胞癌治疗方案的科学证据。
方法：本研究遵循系统评价和荟萃分析（PRISMA）的首选报告项目。我们检索了 MEDLINE（通过 PubMed）来确定评估不可切除口腔鳞状细胞癌治疗的研究。使用 Joanna Briggs Institute (JBI) 检查表工具对纳入研究进行方法学质量评估。使用表格和叙述综合来组织和呈现证据。
结果：33 项研究符合资格标准。大多数研究都有观察性设计。样本量从 16 到 916 名参与者不等。使用 JBI 工具，纳入研究的方法学质量范围为 2.5 到 10。总体而言，无法切除的口腔癌患者的最佳治疗具有挑战性，因此有大量研究评估了多种治疗方案，例如放疗、化疗、同步放化疗、免疫治疗、靶向治疗加化疗或放疗，以及基因治疗加化疗。
结论：缺乏证据表明某些治疗方案对不可切除的口腔鳞状细胞癌的益处。总体而言，这些患者可以使用多模式方法进行治疗，例如同步放化疗或诱导化疗后放化疗，已显示出良好的临床结果。然而，根据风险/益处、肿瘤扩展以及患者价值观和偏好的评估，可以考虑其他选择。

关键词：口腔肿瘤，不可切除的口腔癌，口腔鳞状细胞癌，治疗，治疗