Local biomaterial-assisted antitumour immunotherapy for effusions in the pleural and peritoneal cavities caused by malignancies,Biomaterials Science

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Local biomaterial-assisted antitumour immunotherapy for effusions in the pleural and peritoneal cavities caused by malignancies
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-13 , DOI: 10.1039/d1bm00971k
Yajie Sun ₁ , Yan Hu ₁ , Chao Wan ₁ , Jonathan F Lovell ₂ , Honglin Jin ₁ , Kunyu Yang ₁

Affiliation

Malignant pleural effusion (MPE) and malignant ascites (MA), which are common but serious conditions caused by malignancies, are related to poor quality of life and high mortality. Current treatments, including therapeutic thoracentesis and indwelling pleural catheters or paracentesis and catheter drainage, are largely palliative. An effective treatment is urgently needed. MPE and MA are excellent candidates for intratumoural injections that have direct contact with tumour cells and kill tumour cells more effectively and efficiently with fewer side effects, and the fluid environment of MPE and MA can provide a homogeneous area for drug distribution. The immunosuppressive environments within the pleural and peritoneal cavities suggest the feasibility of local immunotherapy. In this review, we introduce the current management of MPE and MA, discuss the latest advances and challenges in utilizing local biomaterial-assisted antitumour therapies for the treatment of MPE and MA, and discuss further opportunities in this field.

中文翻译：

局部生物材料辅助抗肿瘤免疫治疗恶性肿瘤引起的胸腔和腹腔积液

恶性胸腔积液（MPE）和恶性腹水（MA）是由恶性肿瘤引起的常见但严重的疾病，与生活质量差和死亡率高有关。目前的治疗方法，包括治疗性胸腔穿刺术和留置胸膜导管或穿刺术和导管引流，在很大程度上是姑息性的。迫切需要有效的治疗方法。MPE 和 MA 是瘤内注射的绝佳候选者，它们与肿瘤细胞直接接触，可以更有效地杀死肿瘤细胞，副作用更少，并且 MPE 和 MA 的流体环境可以为药物分布提供均匀的区域。胸膜腔和腹腔内的免疫抑制环境表明局部免疫治疗的可行性。在这篇综述中，我们介绍了 MPE 和 MA 的当前管理，

更新日期：2021-08-25

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