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A highly reproducible SERS sensor based on an Au nanoparticles/graphene oxide hybrid nanocomposite for label-free quantitative detection of antibiotics
Analyst ( IF 3.6 ) Pub Date : 2021-07-30 , DOI: 10.1039/d1an01185e Yan Wang 1 , Huacai Chen 1 , Li Jiang 1
Analyst ( IF 3.6 ) Pub Date : 2021-07-30 , DOI: 10.1039/d1an01185e Yan Wang 1 , Huacai Chen 1 , Li Jiang 1
Affiliation
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Ampicillin and nitrofurantoin, as broad-spectrum antibiotics, are widely used in the prevention of animal diseases and to ensure livestock growth. Large amounts of antibiotic residues exist in animal-derived foods, affecting food quality and safety, causing adverse side effects, such as allergic and toxic reactions, and increasing bacterial resistance. A sensitive surface enhanced Raman scattering (SERS) sensor is provided to detect low-concentration antibiotics (ampicillin and nitrofurantoin). The sensor is based on an Au nanoparticles/graphene oxide hybrid nanocomposite prepared by an in situ reduction method. The detection limits of ampicillin and nitrofurantoin are as low as 0.01 ng mL−1 and 5 ng mL−1, respectively. The relative spectral intensity of the nitrofurantoin characteristic peak has a good linear relationship with the concentration of nitrofurantoin in the range of 500 ng mL−1 and 5 ng mL−1 (R2 = 0.99235). The structure also allows multi-sample measurement for a variety of antibiotics at the same time. The SERS sensor is easy to prepare, with high uniformity and reproducibility, and the sample does not require complex pretreatment and preparation. Sensitive and quantitative detection of antibiotics by the SERS sensor is of great interest in the fields of health care, food preparation, and environmental sampling.
中文翻译：
基于 Au 纳米粒子/氧化石墨烯混合纳米复合材料的高度可重复的 SERS 传感器，用于抗生素的无标记定量检测
氨苄西林和呋喃妥因作为广谱抗生素，被广泛用于预防动物疾病和保障牲畜生长。动物源性食品中存在大量抗生素残留，影响食品质量和安全，引起过敏和毒性反应等不良副作用，增加细菌耐药性。提供灵敏的表面增强拉曼散射 (SERS) 传感器来检测低浓度抗生素（氨苄西林和呋喃妥因）。该传感器基于通过原位还原方法制备的金纳米颗粒/氧化石墨烯混合纳米复合材料。氨苄青霉素和呋喃妥因的检出限低至 0.01 ng mL -1和 5 ng mL -1， 分别。呋喃妥因特征峰的相对光谱强度与呋喃妥因浓度在500 ng mL -1和5 ng mL -1范围内具有良好的线性关系（R 2 = 0.99235）。该结构还允许同时对多种抗生素进行多样品测量。SERS传感器制备简单，均匀性和重现性高，样品不需要复杂的前处理和制备。SERS 传感器对抗生素的灵敏定量检测在医疗保健、食品制备和环境采样领域具有重要意义。
更新日期：2021-08-25
中文翻译：
基于 Au 纳米粒子/氧化石墨烯混合纳米复合材料的高度可重复的 SERS 传感器，用于抗生素的无标记定量检测
氨苄西林和呋喃妥因作为广谱抗生素，被广泛用于预防动物疾病和保障牲畜生长。动物源性食品中存在大量抗生素残留，影响食品质量和安全，引起过敏和毒性反应等不良副作用，增加细菌耐药性。提供灵敏的表面增强拉曼散射 (SERS) 传感器来检测低浓度抗生素（氨苄西林和呋喃妥因）。该传感器基于通过原位还原方法制备的金纳米颗粒/氧化石墨烯混合纳米复合材料。氨苄青霉素和呋喃妥因的检出限低至 0.01 ng mL -1和 5 ng mL -1， 分别。呋喃妥因特征峰的相对光谱强度与呋喃妥因浓度在500 ng mL -1和5 ng mL -1范围内具有良好的线性关系（R 2 = 0.99235）。该结构还允许同时对多种抗生素进行多样品测量。SERS传感器制备简单，均匀性和重现性高，样品不需要复杂的前处理和制备。SERS 传感器对抗生素的灵敏定量检测在医疗保健、食品制备和环境采样领域具有重要意义。
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