Abstract

Inherited thrombophilias are well-established predisposing factors for venous thromboembolism, but their role in arterial ischemic stroke (AIS) in children, remains unclear. The association between SERPINE1 rs1799889 polymorphism and AIS in children was evaluated by several studies, whereas the results were conflicting. Thus, we performed this meta-analysis to combine and analyze the available studies in order to provide a more accurate result on the association. PubMed, Scopus, EMBASE, SciELO, MedRxiv, China Biology Medicine Disk, DeepDyve, CNKI, and Web of Science were used to identify all relevant articles published up to 30 November 2020, without any restrictions on ethnicity. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were used to determine the strength of the associations. A total of eight case-control studies with 600 cases and 2,156 controls were selected. No significant association between SERPINE1 rs1799889 polymorphism and AIS in children susceptibility was noted. In the stratified analyses by ethnicity, source of controls, genotyping methods, and age groups, there was still no significant association between SERPINE1 rs1799889 polymorphism and AIS risk in children. This study suggested that SERPINE1 rs1799889 polymorphism might be not related to etiology of AIS in children. Moreover, well-designed, large-scale and multicenter clinical studies are required to improve and validate these results.

Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1966798 .

摘要

遗传性易栓症是静脉血栓栓塞的公认易感因素，但其在儿童动脉缺血性卒中 (AIS) 中的作用仍不清楚。多项研究评估了 SERPINE1 rs1799889 多态性与儿童 AIS 之间的关联，但结果相互矛盾。因此，我们进行了这项荟萃分析，以结合和分析现有研究，以提供更准确的关联结果。PubMed、Scopus、EMBASE、SciELO、MedRxiv、China Biology Medicine Disk、DeepDyve、CNKI 和 Web of Science 用于识别截至 2020 年 11 月 30 日发表的所有相关文章，对种族没有任何限制。具有 95% 置信区间 (CI) 的汇总优势比 (OR) 用于确定关联的强度。共选择了 8 项病例对照研究，包括 600 例病例和 2,156 名对照。SERPINE1 rs1799889 多态性与儿童易感性 AIS 之间没有显着关联。在按种族、对照来源、基因分型方法和年龄组进行的分层分析中，SERPINE1 rs1799889 多态性与儿童 AIS 风险之间仍然没有显着关联。本研究提示 SERPINE1 rs1799889 多态性可能与儿童 AIS 的病因无关。此外，还需要精心设计、大规模和多中心的临床研究来改进和验证这些结果。基因分型方法和年龄组，SERPINE1 rs1799889 多态性与儿童 AIS 风险之间仍然没有显着关联。本研究提示 SERPINE1 rs1799889 多态性可能与儿童 AIS 的病因无关。此外，还需要精心设计、大规模和多中心的临床研究来改进和验证这些结果。基因分型方法和年龄组，SERPINE1 rs1799889 多态性与儿童 AIS 风险之间仍然没有显着关联。本研究提示 SERPINE1 rs1799889 多态性可能与儿童 AIS 的病因无关。此外，还需要精心设计、大规模和多中心的临床研究来改进和验证这些结果。

本文的补充数据可在 https://doi.org/10.1080/15257770.2021.1966798 在线获取。