The knee joint is one of the largest, most complex, and frequently utilized organs in the body. It is very vulnerable to injuries due to activities, diseases, or accidents, which lead to or cause knee joint injuries in people of all ages. There are several types of knee joint injuries such as contusions, sprains, and strains to the ligament, tendon injuries, cartilage injuries, meniscus injuries, and inflammation of synovial membrane. To date, many drug delivery systems, e.g. nanoparticles, dendrimers, liposomes, micelles, and exosomes, have been used for the treatment of knee joint injuries. They aim to alleviate or reverse the symptoms with an improvement of the function of the knee joint by restoring or curing it. The nanosized structures show good biodegradability, biocompatibility, precise site-specific delivery, prolonged drug release, and enhanced efficacy. They regulate cell proliferation and differentiation, ECM synthesis, proinflammatory factor secretion, etc. to promote repair of injuries. The goal of this review is to outline the finding and studies of the novel strategies of nanotechnology-based drug delivery systems and provide future perspectives to combat the challenges of knee joint injuries by using nanotechnology.

膝关节是人体最大、最复杂、使用频率最高的器官之一。它非常容易因活动、疾病或事故而受到伤害，从而导致或导致所有年龄段人群的膝关节损伤。膝关节损伤有多种类型，例如挫伤、扭伤和韧带拉伤、肌腱损伤、软骨损伤、半月板损伤和滑膜炎症。迄今为止，许多药物递送系统，例如纳米颗粒、树枝状聚合物、脂质体、胶束和外泌体，已被用于治疗膝关节损伤。他们旨在通过恢复或治愈膝关节的功能来缓解或逆转症状。纳米结构显示出良好的生物降解性、生物相容性、精确的位点特异性递送、延长药物释放、并提高疗效。它们调节细胞增殖和分化、ECM合成、促炎因子分泌等，以促进损伤的修复。本综述的目的是概述基于纳米技术的药物递送系统的新策略的发现和研究，并提供未来的前景，以通过使用纳米技术应对膝关节损伤的挑战。